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Akt3 Gene Detail
Summary
  • Symbol
    Akt3
  • Name
    Akt serine/threonine kinase 3
  • Synonyms
    D930002M15Rik, Nmf350, PKB gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345147
    NCBI Gene: 23797
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:176847639-177085769 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 82.66 cM, cytoband H4-H6
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3469 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345147
 protein coding gene Chr1:176847639-177091688 (-)
129S1/SvImJ ENSMUSG00200022977
 protein coding gene Chr1:174599785-174834071 (-)
A/J ENSMUSG00195038760
 protein coding gene Chr1:174037122-174284378 (-)
AKR/J ENSMUSG00220031602
 protein coding gene Chr1:173598421-173846849 (-)
BALB/cJ ENSMUSG00180034904
 protein coding gene Chr1:174250770-174485054 (-)
C3H/HeJ ENSMUSG00175038826
 protein coding gene Chr1:174426877-174661140 (-)
C57BL/6NJ ENSMUSG00215019633
 protein coding gene Chr1:173811105-174051944 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014954
 protein coding gene Chr1:167072951-167310088 (-)
CAST/EiJ ENSTCUG00005045018
 protein coding gene Chr1:172316212-172554815 (-)
CBA/J ENSMUSG00210018587
 protein coding gene Chr1:174078265-174319099 (-)
DBA/2J ENSMUSG00185028308
 protein coding gene Chr1:178697016-178937836 (-)
FVB/NJ ENSMUSG00205020526
 protein coding gene Chr1:173191304-173424739 (-)
JF1/MsJ ENSUMUG00000020508
 protein coding gene Chr1:177574007-177811418 (-)
LP/J ENSMUSG00230029979
 protein coding gene Chr1:178265875-178500139 (-)
NOD/ShiLtJ ENSMUSG00190025283
 protein coding gene Chr1:174112605-174346868 (-)
NZO/HlLtJ ENSMUSG00225004309
 protein coding gene Chr1:181843260-182087772 (-)
PWK/PhJ ENSLUMG00010031433
 protein coding gene Chr1:172819724-173064293 (-)
SPRET/EiJ ENSMSPG00010033392
 protein coding gene Chr1:176456747-176707289 (-)
WSB/EiJ ENSIUOG00005010522
 protein coding gene Chr1:173165230-173406131 (-)



Homology
more
  • Human Ortholog
    AKT3, AKT serine/threonine kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKT3, AKT serine/threonine kinase 3
  • Synonyms
    MPPH, MPPH2, PKBG, PKB-GAMMA, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2
  • Links
    NCBI Gene ID: 10000
    UniProt: Q9Y243

  • Chr Location
    1q43-q44; chr1:243488233-243851079 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human AKT3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    20 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    62
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    89
  • cDNA Data
    11
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019699 Ensembl Gene Model | MGI Sequence Detail 238131 C57BL/6J ±  kb
    transcript ENSMUST00000111159 Ensembl | MGI Sequence Detail 4906 Not Applicable  
    polypeptide ENSMUSP00000106789 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 12
      Primer pair 2
      Other 1
      Antibodies 11

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138357, MGI:3628555
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 34
      Gene Ontology 17
      Phenotypes 64
    • Earliest
      J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
    • Latest
      J:388024 Wang H, et al., CRL4(AMBRA1) is a key mediator for AKT-dependent cell cycle control in neural progenitor cells. EMBO Rep. 2026 Jun;27(11):3099-3119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory