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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Akt3
thymoma viral proto-oncogene 3
MGI:1345147
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Akt1tm1Hem/Akt1+
Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem
involves: 129P2/OlaHsd * C57BL/6 		decreased body size J:114675
decreased body weight J:114675
Akt1tm1Hem/Akt1tm1Hem
Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem
involves: 129P2/OlaHsd * C57BL/6 		prenatal lethality, complete penetrance J:114675
Akt1tm1Nhy/Akt1+
Akt2tm1Rsg/Akt2tm1Rsg
Akt3tm1Nhy/Akt3tm1Nhy
involves: 129/Sv * C57BL/6 * DBA/1LacJ 		hyperglycemia J:149156
Akt1tm1Pnt/Akt1tm1Pnt
Akt2tm1.1Mbb/Akt2tm1.1Mbb
Akt3tm1Mbb/Akt3tm1Mbb
Tg(Lck-cre)1Cwi/0
involves: 129P2/OlaHsd 		arrested T cell differentiation J:135903
decreased double-positive T cell number J:135903
increased double-negative T cell number J:135903
increased T cell apoptosis J:135903
thymus hypoplasia J:135903
Akt1tm1Pnt/Akt1tm1Pnt
Akt3tm1Mbb/Akt3tm1Mbb
Tg(Lck-cre)1Cwi/0
Not Specified 		decreased double-positive T cell number J:135903
thymus hypoplasia J:135903
Akt1tm1Zzy/Akt1tm1Zzy
Akt3tm1Hem/Akt3tm1Hem
Tg(Myh6-cre)1Xya/0
involves: 129P2/OlaHsd * FVB 		abnormal physiological response to xenobiotic J:206783
decreased heart weight J:206783
Akt2tm1.1Mbb/Akt2tm1.1Mbb
Akt3tm1Mbb/Akt3tm1Mbb
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:135903
Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem
involves: 129P2/OlaHsd * C57BL/6 		abnormal testis morphology J:114675
decreased body size J:114675
decreased body weight J:114675
decreased brain weight J:114675
decreased circulating testosterone level J:114675
decreased testis weight J:114675
hyperglycemia J:114675
impaired glucose tolerance J:114675
increased circulating insulin level J:114675
insulin resistance J:114675
Akt2tm1Rsg/Akt2tm1Rsg
Akt3tm1Nhy/Akt3tm1Nhy
involves: 129/Sv * C57BL/6 * DBA/1LacJ 		impaired glucose tolerance J:149156
Akt3tm1Mbb/Akt3tm1Mbb
Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
involves: 129 * C57BL/6 * FVB/N 		increased mammary adenocarcinoma incidence J:117336
Akt3tm1Mbb/Akt3tm1Mbb
Tg(MMTV-PyVT)634Mul/0
involves: 129 * C57BL/6 * FVB/N 		increased mammary adenocarcinoma incidence J:117336
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory