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Hpse Gene Detail
Summary
  • Symbol
    Hpse
  • Name
    heparanase
  • Synonyms
    Hpa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343124
    NCBI Gene: 15442
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100827350-100867582 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1365 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343124
 protein coding gene Chr5:100827350-100867582 (-)
129S1/SvImJ ENSMUSG00200005207
 protein coding gene Chr5:94575152-94615436 (-)
A/J ENSMUSG00195033688
 protein coding gene Chr5:94135859-94176093 (-)
AKR/J ENSMUSG00220035911
 protein coding gene Chr5:93605901-93646131 (-)
BALB/cJ ENSMUSG00180034077
 protein coding gene Chr5:94292083-94332309 (-)
C3H/HeJ ENSMUSG00175030452
 protein coding gene Chr5:96396724-96436946 (-)
C57BL/6NJ ENSMUSG00215009041
 protein coding gene Chr5:94212744-94252982 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027456
 protein coding gene Chr5:93621317-93660898 (-)
CAST/EiJ ENSTCUG00005023837
 protein coding gene Chr5:93606281-93647208 (-)
CBA/J ENSMUSG00210032481
 protein coding gene Chr5:95147052-95187287 (-)
DBA/2J ENSMUSG00185033876
 protein coding gene Chr5:98065405-98105645 (-)
FVB/NJ ENSMUSG00205028655
 protein coding gene Chr5:94042181-94082423 (-)
JF1/MsJ ENSUMUG00000038587
 protein coding gene Chr5:101029655-101072576 (-)
LP/J ENSMUSG00230023504
 protein coding gene Chr5:102116786-102157060 (-)
NOD/ShiLtJ ENSMUSG00190022640
 protein coding gene Chr5:94043244-94083479 (-)
NZO/HlLtJ ENSMUSG00225012411
 protein coding gene Chr5:109881123-109921342 (-)
PWK/PhJ ENSLUMG00010012913
 protein coding gene Chr5:93154091-93194455 (-)
SPRET/EiJ ENSMSPG00010023199
 protein coding gene Chr5:96045993-96086172 (-)
WSB/EiJ ENSIUOG00005028399
 protein coding gene Chr5:96779263-96820098 (-)



Homology
more
  • Human Ortholog
    HPSE, heparanase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPSE, heparanase
  • Synonyms
    HPA, HPA1, HPR1, HPSE1, HSE1
  • Links
    NCBI Gene ID: 10855
    UniProt: Q9Y251

  • Chr Location
    4q21.23; chr4:83292461-83335153 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit precocious mammry gland development, increased angiogenesis and increased neovascularization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    137
  • cDNA Data
    33
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15442 NCBI Gene Model | MGI Sequence Detail 40233 C57BL/6J ±  kb
    transcript NM_152803 RefSeq | MGI Sequence Detail 3140 Not Specified  
    polypeptide Q6YGZ1 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 3
      Antibodies 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 52
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:378765 Wu SJ, et al., Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature. 2026 Jan 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory