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Fanca Gene Detail
Summary
  • Symbol
    Fanca
  • Name
    Fanconi anemia, complementation group A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341823
    NCBI Gene: 14087
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123995039-124045315 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.10 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1972 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341823
 protein coding gene Chr8:123993033-124045390 (-)
129S1/SvImJ ENSMUSG00200042854
 protein coding gene Chr8:118325002-118373868 (-)
A/J ENSMUSG00195026286
 protein coding gene Chr8:118617483-118667368 (-)
AKR/J ENSMUSG00220038377
 protein coding gene Chr8:118807215-118863142 (-)
BALB/cJ ENSMUSG00180023608
 protein coding gene Chr8:118663466-118713347 (-)
C3H/HeJ ENSMUSG00175030094
 protein coding gene Chr8:118719120-118775056 (-)
C57BL/6NJ ENSMUSG00215025204
 protein coding gene Chr8:118301342-118351618 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031686
 protein coding gene Chr8:114434479-114487185 (-)
CAST/EiJ ENSTCUG00005031447
 protein coding gene Chr8:118037941-118090473 (-)
CBA/J ENSMUSG00210032401
 protein coding gene Chr8:118653780-118702302 (-)
DBA/2J ENSMUSG00185033700
 protein coding gene Chr8:124758713-124807243 (-)
FVB/NJ ENSMUSG00205027384
 protein coding gene Chr8:117620012-117670291 (-)
JF1/MsJ ENSUMUG00000020300
 protein coding gene Chr8:127057143-127107033 (-)
LP/J ENSMUSG00230028581
 protein coding gene Chr8:128376405-128425267 (-)
NOD/ShiLtJ ENSMUSG00190018203
 protein coding gene Chr8:118754256-118804538 (-)
NZO/HlLtJ ENSMUSG00225041745
 protein coding gene Chr8:131759186-131809410 (-)
PWK/PhJ ENSLUMG00010032130
 protein coding gene Chr8:118461482-118511613 (-)
SPRET/EiJ ENSMSPG00010036687
 protein coding gene Chr8:120650148-120700667 (-)
WSB/EiJ ENSIUOG00005027598
 protein coding gene Chr8:119439286-119489037 (-)



Homology
more
  • Human Ortholog
    FANCA, FA complementation group A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FANCA, FA complementation group A
  • Synonyms
    FA, FA1, FAA, FACA, FA-H, FAH, FANCH
  • Links
    NCBI Gene ID: 2175
    UniProt: O15360

  • Chr Location
    16q24.3; chr16:89726683-89816977 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fanca mouse models; 11 with human FANCA associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 5 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants show variably: growth retardation, microphthalmia, craniofacial malformations and hematological changes, depending on allele and strain background. Both sexes show hypogonadism, including diminished primordial germ cells and impaired fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    41
  • cDNA Data
    12
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032815 Ensembl Gene Model | MGI Sequence Detail 50277 C57BL/6J ±  kb
    transcript ENSMUST00000035495 Ensembl | MGI Sequence Detail 4485 Not Applicable  
    polypeptide ENSMUSP00000045217 Ensembl | MGI Sequence Detail 1439 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000007330 Fanconi anemia group A protein
      (term hierarchy)
    • InterPro Domains
      IPR003516 Fanconi anaemia group A protein
      IPR055387 Fanconi anaemia group A protein, arcN subdomain
      IPR055277 Fanconi anaemia group A protein, C-terminal
      IPR055386 Fanconi anaemia group A protein, helical domain
      IPR031729 Fanconi anaemia group A protein, N-terminal domain
    • GlyGen
      Q9JL70 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 15
      Primer pair 5
      Other 2
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142773
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 8
      Phenotypes 51
    • Earliest
      J:56258 Abu-Issa R, et al., Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Blood. 1999 Jul 15;94(2):818-24
    • Latest
      J:386080 Sheth AS, et al., PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia. Cancer Res Commun. 2025 Apr 1;5(4):648-667
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory