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Orc1 Gene Detail
Summary
  • Symbol
    Orc1
  • Name
    origin recognition complex, subunit 1
  • Synonyms
    MmORC1, Orc1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328337
    NCBI Gene: 18392
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:108436651-108472030 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.64 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1019 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328337
 protein coding gene Chr4:108436620-108472030 (+)
129S1/SvImJ ENSMUSG00200047314
 protein coding gene Chr4:103487168-103524762 (+)
A/J ENSMUSG00195043924
 protein coding gene Chr4:104030188-104067784 (+)
AKR/J ENSMUSG00220011836
 protein coding gene Chr4:103416167-103453531 (+)
BALB/cJ ENSMUSG00180044013
 protein coding gene Chr4:102858649-102896266 (+)
C3H/HeJ ENSMUSG00175035813
 protein coding gene Chr4:103863049-103900660 (+)
C57BL/6NJ ENSMUSG00215014785
 protein coding gene Chr4:103768928-103805687 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026270
 protein coding gene Chr4:100678690-100710317 (+)
CAST/EiJ ENSTCUG00005020767
 protein coding gene Chr4:102973230-103010651 (+)
CBA/J ENSMUSG00210052323
 protein coding gene Chr4:103496067-103533679 (+)
DBA/2J ENSMUSG00185045033
 protein coding gene Chr4:104207246-104244809 (+)
FVB/NJ ENSMUSG00205019762
 protein coding gene Chr4:102440540-102478138 (+)
JF1/MsJ ENSUMUG00000044284
 protein coding gene Chr4:104220860-104258319 (+)
LP/J ENSMUSG00230006140
 protein coding gene Chr4:107523535-107561124 (+)
NOD/ShiLtJ ENSMUSG00190038873
 protein coding gene Chr4:102865831-102903443 (+)
NZO/HlLtJ ENSMUSG00225032026
 protein coding gene Chr4:112625765-112663332 (+)
PWK/PhJ ENSLUMG00010040368
 protein coding gene Chr4:101936000-101973473 (+)
SPRET/EiJ ENSMSPG00010025392
 protein coding gene Chr4:104159480-104195757 (+)
WSB/EiJ ENSIUOG00005034934
 protein coding gene Chr4:103067764-103104333 (+)



Homology
more
  • Human Ortholog
    ORC1, origin recognition complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORC1, origin recognition complex subunit 1
  • Synonyms
    HSORC1, ORC1L, PARC1
  • Links
    NCBI Gene ID: 4998
    UniProt: Q13415

  • Chr Location
    1p32.3; chr1:52372010-52409503 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ORC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 6 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete peri-implantation lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    5
  • cDNA Data
    48
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18392 NCBI Gene Model | MGI Sequence Detail 35380 C57BL/6J ±  kb
    transcript NM_011015 RefSeq | MGI Sequence Detail 3027 C57BL/6  
    polypeptide Q9Z1N2 UniProt | EBI | MGI Sequence Detail 840 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140163
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:51511 Zisimopoulou P, et al., Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1. Mol Gen Genet. 1998 Nov;260(2-3):295-9
    • Latest
      J:368206 Garcia-Juan M, et al., Clearance of beta-amyloid mediated by autophagy is enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes. Glia. 2024 Mar;72(3):588-606
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory