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Ncoa2 Gene Detail
Summary
  • Symbol
    Ncoa2
  • Name
    nuclear receptor coactivator 2
  • Synonyms
    bHLHe75, D1Ertd433e, glucocorticoid receptor-interacting protein 1, Grip1, KAT13C, SRC-2, TIF-2, TIF2, TIF2/GRIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276533
    NCBI Gene: 17978
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:13209329-13444307 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.12 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6145 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276533
 protein coding gene Chr1:13209329-13444451 (-)
129S1/SvImJ ENSMUSG00200018313
 protein coding gene Chr1:10534409-10762839 (-)
A/J ENSMUSG00195026562
 protein coding gene Chr1:10361687-10590119 (-)
AKR/J ENSMUSG00220008094
 protein coding gene Chr1:10432201-10660653 (-)
BALB/cJ ENSMUSG00180023661
 protein coding gene Chr1:10428019-10656455 (-)
C3H/HeJ ENSMUSG00175000173
 protein coding gene Chr1:10356793-10585231 (-)
C57BL/6NJ ENSMUSG00215009420
 protein coding gene Chr1:10404566-10639677 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013954
 protein coding gene Chr1:9100095-9328283 (-)
CAST/EiJ ENSTCUG00005021837
 protein coding gene Chr1:10811697-11040298 (-)
CBA/J ENSMUSG00210002596
 protein coding gene Chr1:10227262-10455688 (-)
DBA/2J ENSMUSG00185003728
 protein coding gene Chr1:11305296-11533346 (-)
FVB/NJ ENSMUSG00205012920
 protein coding gene Chr1:10515690-10744083 (-)
JF1/MsJ ENSUMUG00000011474
 protein coding gene Chr1:10596622-10825275 (-)
LP/J ENSMUSG00230018369
 protein coding gene Chr1:11263755-11492174 (-)
NOD/ShiLtJ ENSMUSG00190024367
 protein coding gene Chr1:10335243-10563640 (-)
NZO/HlLtJ ENSMUSG00225004460
 protein coding gene Chr1:14660537-14888607 (-)
PWK/PhJ ENSLUMG00010020967
 protein coding gene Chr1:10191505-10420024 (-)
SPRET/EiJ ENSMSPG00010026128
 protein coding gene Chr1:10880399-11116516 (-)
WSB/EiJ ENSIUOG00005011192
 protein coding gene Chr1:10365033-10595604 (-)



Homology
more
  • Human Ortholog
    NCOA2, nuclear receptor coactivator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOA2, nuclear receptor coactivator 2
  • Synonyms
    bHLHe75, GRIP1, KAT13C, NCoA-2, SRC-2, SRC2, TIF2
  • Links
    NCBI Gene ID: 10499
    UniProt: Q15596

  • Chr Location
    8q13.3; chr8:70109772-70456446 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human NCOA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a transient postnatal growth deficiency and hypofertility. Male hypofertility is due to defects in spermiogenesis and an age-dependent testicular degeneration preceded by defective lipid metabolism in Sertoli cells. Female hypofertility is due to a placental hypoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    197
  • cDNA Data
    109
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005886 Ensembl Gene Model | MGI Sequence Detail 234979 C57BL/6J ±  kb
    transcript ENSMUST00000006037 Ensembl | MGI Sequence Detail 4897 Not Applicable  
    polypeptide ENSMUSP00000006037 Ensembl | MGI Sequence Detail 1462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 124
      Genomic 1
      cDNA 114
      Primer pair 9
      Antibodies 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35900, MGI:107429, MGI:1196270
    References
    more
    • Summaries
      All 162
      Developmental Gene Expression 19
      Gene Ontology 33
      Phenotypes 60
    • Earliest
      J:33918 Hong H, et al., GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4948-52
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory