Automated description from the Alliance of Genome Resources (Release 9.0.0)
Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including 4-8 cell stage conceptus; blastocyst-stage conceptus; central nervous system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2).
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