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Prep Gene Detail
Summary
  • Symbol
    Prep
  • Name
    prolyl endopeptidase
  • Synonyms
    D10Wsu136e, Pop, prolyl oligopeptidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270863
    NCBI Gene: 19072
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:44943312-45038847 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 23.27 cM, cytoband B2-B3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3443 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270863
 protein coding gene Chr10:44943299-45043294 (+)
129S1/SvImJ ENSMUSG00200006888
 protein coding gene Chr10:41841605-41941608 (+)
A/J ENSMUSG00195002812
 protein coding gene Chr10:42111456-42211474 (+)
AKR/J ENSMUSG00220005810
 protein coding gene Chr10:41797308-41897314 (+)
BALB/cJ ENSMUSG00180011628
 protein coding gene Chr10:42200607-42300619 (+)
C3H/HeJ ENSMUSG00175009727
 protein coding gene Chr10:41993350-42093340 (+)
C57BL/6NJ ENSMUSG00215002119
 protein coding gene Chr10:41738160-41838161 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015296
 protein coding gene Chr10:40602367-40698736 (+)
CAST/EiJ ENSTCUG00005008454
 protein coding gene Chr10:42181702-42282681 (+)
CBA/J ENSMUSG00210008045
 protein coding gene Chr10:41883754-41983738 (+)
DBA/2J ENSMUSG00185003202
 protein coding gene Chr10:42035293-42135289 (+)
FVB/NJ ENSMUSG00205004675
 protein coding gene Chr10:41955686-42055628 (+)
JF1/MsJ ENSUMUG00000017978
 protein coding gene Chr10:41866154-41967135 (+)
LP/J ENSMUSG00230005283
 protein coding gene Chr10:43839542-43939543 (+)
NOD/ShiLtJ ENSMUSG00190005409
 protein coding gene Chr10:42163456-42263460 (+)
NZO/HlLtJ ENSMUSG00225016269
 protein coding gene Chr10:48125074-48225069 (+)
PWK/PhJ ENSLUMG00010004506
 protein coding gene Chr10:41949833-42051551 (+)
SPRET/EiJ ENSMSPG00010012269
 protein coding gene Chr10:42999862-43092193 (+)
WSB/EiJ ENSIUOG00005014837
 protein coding gene Chr10:41718252-41818161 (+)



Homology
more
  • Human Ortholog
    PREP, prolyl endopeptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PREP, prolyl endopeptidase
  • Synonyms
    PE, PEP
  • Links
    NCBI Gene ID: 5550
    UniProt: P48147

  • Chr Location
    6q21; chr6:105273218-105454062 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit sex-dependent resistance to diet-induced obesity and adiposity. Mice heterozygous for a gene trap allele exhibit maternal inheritance influenced increase in body weight, organ weight, and adiposity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    659
  • Tissues
    13
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19072 NCBI Gene Model | MGI Sequence Detail 95536 C57BL/6J ±  kb
    transcript NM_011156 RefSeq | MGI Sequence Detail 6494 ZRU/MplStud  
    polypeptide Q9QUR6 UniProt | EBI | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35736, MGI:107271, MGI:2143520, MGI:2143608
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory