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Cidea Gene Detail
Summary
  • Symbol
    Cidea
  • Name
    cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270845
    NCBI Gene: 12683
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:67476674-67500855 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    913 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270845
 protein coding gene Chr18:67476634-67500864 (+)
129S1/SvImJ ENSMUSG00200023500
 protein coding gene Chr18:64672483-64696661 (+)
A/J ENSMUSG00195029459
 protein coding gene Chr18:64715059-64739170 (+)
AKR/J ENSMUSG00220021593
 protein coding gene Chr18:64686903-64711082 (+)
BALB/cJ ENSMUSG00180011248
 protein coding gene Chr18:65282189-65306292 (+)
C3H/HeJ ENSMUSG00175009955
 protein coding gene Chr18:64889682-64913862 (+)
C57BL/6NJ ENSMUSG00215009793
 protein coding gene Chr18:64236428-64260610 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022366
 protein coding gene Chr18:64048832-64073537 (+)
CAST/EiJ ENSTCUG00005014984
 protein coding gene Chr18:63883405-63907351 (+)
CBA/J ENSMUSG00210029042
 protein coding gene Chr18:64842697-64866879 (+)
DBA/2J ENSMUSG00185029721
 protein coding gene Chr18:64754024-64778198 (+)
FVB/NJ ENSMUSG00205012066
 protein coding gene Chr18:64216850-64241042 (+)
JF1/MsJ ENSUMUG00000023173
 protein coding gene Chr18:64669640-64693602 (+)
LP/J ENSMUSG00230035209
 protein coding gene Chr18:66804937-66829109 (+)
NOD/ShiLtJ ENSMUSG00190007791
 protein coding gene Chr18:64476677-64500856 (+)
NZO/HlLtJ ENSMUSG00225030237
 protein coding gene Chr18:66694092-66718264 (+)
PWK/PhJ ENSLUMG00010024281
 protein coding gene Chr18:65055637-65081963 (+)
SPRET/EiJ ENSMSPG00010036585
 protein coding gene Chr18:65219833-65242311 (+)
WSB/EiJ ENSIUOG00005005575
 protein coding gene Chr18:64281759-64312263 (+)



Homology
more
  • Human Ortholog
    CIDEA, cell death inducing DFFA like effector a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIDEA, cell death inducing DFFA like effector a
  • Synonyms
    CIDE-A
  • Links
    NCBI Gene ID: 1149
    UniProt: O60543

  • Chr Location
    18p11.21; chr18:12254361-12277595 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CIDEA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show higher metabolic rate, lipolysis in BAT and core body temperature when subjected to cold treatment. They are lean and resistant to diet-induced obesity. Aging homozygotes exhibit dry eyes and hair, reduced sebaceous lipid secretion, hair loss, and poor water repulsion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    10
  • cDNA Data
    60
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024526 Ensembl Gene Model | MGI Sequence Detail 24182 C57BL/6J ±  kb
    transcript ENSMUST00000025404 Ensembl | MGI Sequence Detail 1115 Not Applicable  
    polypeptide ENSMUSP00000025404 Ensembl | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 60
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147356
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 37
      Gene Ontology 20
      Phenotypes 19
    • Earliest
      J:47647 Inohara N, et al., CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998 May 1;17(9):2526-33
    • Latest
      J:388916 Xia R, et al., Therapeutic restoration of miR-96 prevents hearing loss in mice through modulation of noise-induced and genetic pathways. iScience. 2025 May 16;28(5):112355
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory