About   Help   FAQ
Dsc3 Gene Detail
Summary
  • Symbol
    Dsc3
  • Name
    desmocollin 3
  • Synonyms
    5430426I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194993
    NCBI Gene: 13507
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:20093987-20135408 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1499 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194993
 protein coding gene Chr18:20093987-20135465 (-)
129S1/SvImJ ENSMUSG00200019374
 protein coding gene Chr18:17101634-17143058 (-)
A/J ENSMUSG00195002014
 protein coding gene Chr18:17242494-17284259 (-)
AKR/J ENSMUSG00220011542
 protein coding gene Chr18:17287141-17328908 (-)
BALB/cJ ENSMUSG00180003911
 protein coding gene Chr18:17703833-17745617 (-)
C3H/HeJ ENSMUSG00175004366
 protein coding gene Chr18:17230071-17271844 (-)
C57BL/6NJ ENSMUSG00215003431
 protein coding gene Chr18:16942688-16984462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022021
 protein coding gene Chr18:16163151-16207974 (-)
CAST/EiJ ENSTCUG00005014705
 protein coding gene Chr18:16958505-17009211 (-)
CBA/J ENSMUSG00210020006
 protein coding gene Chr18:17256208-17297971 (-)
DBA/2J ENSMUSG00185007823
 protein coding gene Chr18:17213359-17255186 (-)
FVB/NJ ENSMUSG00205016522
 protein coding gene Chr18:16951595-16993415 (-)
JF1/MsJ ENSUMUG00000017372
 protein coding gene Chr18:17264996-17306760 (-)
LP/J ENSMUSG00230010546
 protein coding gene Chr18:19295735-19337159 (-)
NOD/ShiLtJ ENSMUSG00190016631
 protein coding gene Chr18:17028410-17070227 (-)
NZO/HlLtJ ENSMUSG00225027963
 protein coding gene Chr18:19218408-19260164 (-)
PWK/PhJ ENSLUMG00010015265
 protein coding gene Chr18:17443281-17484932 (-)
SPRET/EiJ ENSMSPG00010004731
 protein coding gene Chr18:17353805-17393028 (-)
WSB/EiJ ENSIUOG00005018599
 protein coding gene Chr18:17118242-17159592 (-)



Homology
more
  • Human Ortholog
    DSC3, desmocollin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSC3, desmocollin 3
  • Synonyms
    CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP
  • Links
    NCBI Gene ID: 1825
    UniProt: Q14574

  • Chr Location
    18q12.1; chr18:30989365-31042815 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die before implantation. Heterozygous mice do not display any gross abnormalities and have normal epidermal development and keratinocyte differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    128
  • cDNA Data
    26
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059898 Ensembl Gene Model | MGI Sequence Detail 41422 C57BL/6J ±  kb
    transcript ENSMUST00000225110 Ensembl | MGI Sequence Detail 3123 Not Applicable  
    polypeptide ENSMUSP00000153261 Ensembl | MGI Sequence Detail 896 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 28
      Primer pair 7
      Other 2
      Antibodies 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918578
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 20
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:18927 Buxton RS, et al., Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. Genomics. 1994 Jun;21(3):510-6
    • Latest
      J:376269 Nakashima Y, et al., Identification of a desmocollin 3-beta-catenin complex modulated by Vwde-calpain signaling in ameloblast differentiation. Biochem Biophys Res Commun. 2025 Dec 15;792:153000
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory