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Slc18a3 Gene Detail
Summary
  • Symbol
    Slc18a3
  • Name
    solute carrier family 18 (vesicular monoamine), member 3
  • Synonyms
    VAChT, VAT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101061
    NCBI Gene: 20508
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32184395-32186807 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101061
 protein coding gene Chr14:32184394-32186807 (-)
129S1/SvImJ ENSMUSG00200037898
 protein coding gene Chr14:24007992-24010405 (-)
A/J ENSMUSG00195013818
 protein coding gene Chr14:25082068-25084480 (-)
AKR/J ENSMUSG00220034766
 protein coding gene Chr14:24194411-24196823 (-)
BALB/cJ ENSMUSG00180025823
 protein coding gene Chr14:24170598-24173010 (-)
C3H/HeJ ENSMUSG00175035564
 protein coding gene Chr14:24237806-24240218 (-)
C57BL/6NJ ENSMUSG00215021420
 protein coding gene Chr14:24474434-24476846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019092
 protein coding gene Chr14:24797492-24799904 (-)
CAST/EiJ ENSTCUG00005021234
 protein coding gene Chr14:24316871-24319287 (-)
CBA/J ENSMUSG00210041604
 protein coding gene Chr14:24480716-24483128 (-)
DBA/2J ENSMUSG00185040079
 protein coding gene Chr14:28750080-28752492 (-)
FVB/NJ ENSMUSG00205031947
 protein coding gene Chr14:24341785-24344198 (-)
JF1/MsJ ENSUMUG00000048783
 protein coding gene Chr14:36012270-36014680 (-)
LP/J ENSMUSG00230037334
 protein coding gene Chr14:36031962-36034375 (-)
NOD/ShiLtJ ENSMUSG00190018248
 protein coding gene Chr14:24494329-24496741 (-)
NZO/HlLtJ ENSMUSG00225035846
 protein coding gene Chr14:30369022-30371434 (-)
PWK/PhJ ENSLUMG00010022356
 protein coding gene Chr14:12602207-12604617 (-)
SPRET/EiJ ENSMSPG00010033738
 protein coding gene Chr14:26166541-26168958 (-)
WSB/EiJ ENSIUOG00005011006
 protein coding gene Chr14:24305245-24307658 (-)



Homology
more
  • Human Ortholog
    SLC18A3, solute carrier family 18 member A3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC18A3, solute carrier family 18 member A3
  • Synonyms
    CMS21, VACHT
  • Links
    NCBI Gene ID: 6572
    UniProt: Q16572

  • Chr Location
    10q11.23; chr10:49610310-49612720 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC18A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased acetylcholine release, grip strength, coordination, exercise endurance, and social recognition memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    111
  • cDNA Data
    8
  • Literature Summary
    115
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000100241 Ensembl Gene Model | MGI Sequence Detail 2413 C57BL/6J ±  kb
transcript ENSMUST00000191501 Ensembl | MGI Sequence Detail 2413 Not Applicable  
polypeptide ENSMUSP00000139829 Ensembl | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 9
    Primer pair 2
    Other 4
    Antibodies 9

    Microarray probesets 3
References
more
  • Summaries
    All 232
    Developmental Gene Expression 115
    Gene Ontology 16
    Phenotypes 44
  • Earliest
    J:263491 Carroll PT, The effect of the acetylcholine transport blocker 2-(4-phenylpiperidino) cyclohexanol (AH5183) on the subcellular storage and release of acetylcholine in mouse brain. Brain Res. 1985 Dec 9;358(1-2):200-9
  • Latest
    J:382965 Molitor J, et al., Altered striosome-matrix distribution and activity of striatal cholinergic interneurons in a model of autism-linked repetitive behaviors. Mol Psychiatry. 2026 Feb;31(2):997-1013
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory