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Kif12 Gene Detail
Summary
  • Symbol
    Kif12
  • Name
    kinesin family member 12
  • Synonyms
    N-9 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098232
    NCBI Gene: 16552
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63083867-63090368 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.96 cM, cytoband C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098232
 protein coding gene Chr4:63076185-63090382 (-)
129S1/SvImJ ENSMUSG00200002902
 protein coding gene Chr4:58057213-58063729 (-)
A/J ENSMUSG00195008104
 protein coding gene Chr4:58640681-58647197 (-)
AKR/J ENSMUSG00220005070
 protein coding gene Chr4:58449076-58455592 (-)
BALB/cJ ENSMUSG00180028718
 protein coding gene Chr4:57626555-57633071 (-)
C3H/HeJ ENSMUSG00175020647
 protein coding gene Chr4:58409311-58415827 (-)
C57BL/6NJ ENSMUSG00215016452
 protein coding gene Chr4:58480420-58486936 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026089
 protein coding gene Chr4:57257963-57264533 (-)
CAST/EiJ ENSTCUG00005008210
 protein coding gene Chr4:58222190-58228727 (-)
CBA/J ENSMUSG00210005705
 protein coding gene Chr4:58160029-58166545 (-)
DBA/2J ENSMUSG00185017340
 protein coding gene Chr4:58576505-58583021 (-)
FVB/NJ ENSMUSG00205016776
 protein coding gene Chr4:56849063-56855579 (-)
JF1/MsJ ENSUMUG00000020443
 protein coding gene Chr4:59206429-59212957 (-)
LP/J ENSMUSG00230009759
 protein coding gene Chr4:62067133-62073649 (-)
NOD/ShiLtJ ENSMUSG00190027945
 protein coding gene Chr4:57558694-57565210 (-)
NZO/HlLtJ ENSMUSG00225013023
 protein coding gene Chr4:67095339-67101855 (-)
PWK/PhJ ENSLUMG00010007264
 protein coding gene Chr4:56833211-56839739 (-)
SPRET/EiJ ENSMSPG00010031646
 protein coding gene Chr4:58095821-58102358 (-)
WSB/EiJ ENSIUOG00005020094
 protein coding gene Chr4:57897830-57904346 (-)



Homology
more
  • Human Ortholog
    KIF12, kinesin family member 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF12, kinesin family member 12
  • Synonyms
    PFIC8
  • Links
    NCBI Gene ID: 113220
    UniProt: Q96FN5

  • Chr Location
    9q32; chr9:114086126-114099292 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kif12 mouse models; 1 with human KIF12 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    7
  • cDNA Data
    21
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028357 Ensembl Gene Model | MGI Sequence Detail 6502 C57BL/6J ±  kb
    transcript ENSMUST00000156618 Ensembl | MGI Sequence Detail 2258 Not Applicable  
    polypeptide ENSMUSP00000152690 Ensembl | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 21
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
    • Latest
      J:371295 Etemad A, et al., Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover. EMBO J. 2025 Mar;44(6):1608-1640
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory