Phenotypes Associated with This Genotype

Genotype
MGI:8242626

• Allelic Composition: Kif12^em1Noh/Kif12^em1Noh
• Genetic Background: C57BL/6-Kif12^em1Noh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased liver triglyceride level ( J:371295 )

Mallory bodies ( J:371295 )

hepatic steatosis ( J:371295 )

• mice show metabolic dysfunction-associated steatohepatitis, including microsteatosis, Mallory-Denk bodies, and atypical nuclei in zone 3 area, indicating liver steatosis without signs of cholestasis

microvesicular hepatic steatosis ( J:371295 )

• mice show metabolic dysfunction-associated steatohepatitis, including microsteatosis

liver fibrosis ( J:371295 )

• perisinusoidal fibrosis in zone 3

abnormal liver physiology ( J:371295 )

• carnitine palmitoyltransferase activity of 8-week-old livers is reduced suggesting that fatty acid metabolism is impaired

liver inflammation ( J:371295 )

• mice show metabolic dysfunction-associated steatohepatitis

homeostasis/metabolism

increased circulating bilirubin level ( J:371295 )

increased circulating alanine transaminase level ( J:371295 )

increased circulating alkaline phosphatase level ( J:371295 )

increased circulating aspartate transaminase level ( J:371295 )

increased lactate dehydrogenase level ( J:371295 )

increased liver triglyceride level ( J:371295 )

increased alpha-fetoprotein level ( J:371295 )

• serum alpha-fetoprotein is increased

immune system

liver inflammation ( J:371295 )

• mice show metabolic dysfunction-associated steatohepatitis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
metabolic dysfunction-associated steatohepatitis		DOID:0080547		J:371295