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Trim28 Gene Detail
Summary
  • Symbol
    Trim28
  • Name
    tripartite motif-containing 28
  • Synonyms
    KAP-1, KRIP-1, MommeD9, Tif1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109274
    NCBI Gene: 21849
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:12758079-12764959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 7.73 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109274
 protein coding gene Chr7:12733041-12764962 (+)
129S1/SvImJ ENSMUSG00200039640
 protein coding gene Chr7:6799184-6807754 (+)
A/J ENSMUSG00195046463
 protein coding gene Chr7:6483715-6492286 (+)
AKR/J ENSMUSG00220022991
 protein coding gene Chr7:5966166-5974737 (+)
BALB/cJ ENSMUSG00180047656
 protein coding gene Chr7:6406854-6415425 (+)
C3H/HeJ ENSMUSG00175036395
 protein coding gene Chr7:6852541-6861107 (+)
C57BL/6NJ ENSMUSG00215043296
 protein coding gene Chr7:7080186-7088751 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029198
 protein coding gene Chr7:11870063-11877240 (+)
CAST/EiJ ENSTCUG00005027600
 protein coding gene Chr7:6561076-6569623 (+)
CBA/J ENSMUSG00210045990
 protein coding gene Chr7:6122293-6130863 (+)
DBA/2J ENSMUSG00185042187
 protein coding gene Chr7:9654944-9663514 (+)
FVB/NJ ENSMUSG00205030971
 protein coding gene Chr7:6866644-6875210 (+)
JF1/MsJ ENSUMUG00000037528
 protein coding gene Chr7:9303029-9311576 (+)
LP/J ENSMUSG00230043025
 protein coding gene Chr7:13837459-13846029 (+)
NOD/ShiLtJ ENSMUSG00190048878
 protein coding gene Chr7:10745512-10754077 (+)
NZO/HlLtJ ENSMUSG00225053331
 protein coding gene Chr7:11318454-11327020 (+)
PWK/PhJ ENSLUMG00010041764
 protein coding gene Chr7:10469194-10477736 (+)
SPRET/EiJ ENSMSPG00010038608
 protein coding gene Chr7:6632761-6639632 (+)
WSB/EiJ ENSIUOG00005051810
 protein coding gene Chr7:18415715-18424277 (-)



Homology
more
  • Human Ortholog
    TRIM28, tripartite motif containing 28
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM28, tripartite motif containing 28
  • Synonyms
    KAP1, PPP1R157, RNF96, TF1B, TIF1B, TIF1beta, WT7
  • Links
    NCBI Gene ID: 10155
    UniProt: Q13263

  • Chr Location
    19q13.43; chr19:58543740-58550773 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 7 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted disruption of this gene develop normally until the blastocyst stage and undergo uterine implantation, but become arrested at the early egg-cylinder stage, fail to gastrulate, and are completely resorbed by E8.5. Conditional homozygous KO in ovaries leads to masculinization of follicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    146
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    237
  • cDNA Data
    24
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21849 NCBI Gene Model | MGI Sequence Detail 6881 C57BL/6J ±  kb
    transcript NM_011588 RefSeq | MGI Sequence Detail 3255 C57BL/6  
    polypeptide Q62318 UniProt | EBI | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 24
      Primer pair 4
      Other 2
      Antibodies 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38319, MGI:2138086, MGI:3821594
    References
    more
    • Summaries
      All 210
      Developmental Gene Expression 43
      Gene Ontology 34
      Phenotypes 59
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:391359 Palhazi B, et al., The absence of Trim28 in nephron progenitors results in impaired kidney development and function. Development. 2026 Aug 1;153(15):dev205188
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory