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Pfkfb2 Gene Detail
Summary
  • Symbol
    Pfkfb2
  • Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  • Synonyms
    4930568D07Rik, PFK-2/FBPase-2 gene B
  • Feature Type
    protein coding gene
  • IDs
    MGI:107815
    NCBI Gene: 18640
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:130616919-130656990 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.89 cM, cytoband E4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    943 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107815
 protein coding gene Chr1:130616780-130656990 (-)
129S1/SvImJ ENSMUSG00200007391
 protein coding gene Chr1:128187781-128213177 (-)
A/J ENSMUSG00195039854
 protein coding gene Chr1:127279153-127319223 (-)
AKR/J ENSMUSG00220045310
 protein coding gene Chr1:127125455-127165526 (-)
BALB/cJ ENSMUSG00180036924
 protein coding gene Chr1:127842337-127882406 (-)
C3H/HeJ ENSMUSG00175037798
 protein coding gene Chr1:127523880-127549274 (-)
C57BL/6NJ ENSMUSG00215044939
 protein coding gene Chr1:127539471-127579550 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014556
 protein coding gene Chr1:122269822-122310027 (-)
CAST/EiJ ENSTCUG00005028914
 protein coding gene Chr1:126461298-126501435 (-)
CBA/J ENSMUSG00210026522
 protein coding gene Chr1:127436308-127476455 (-)
DBA/2J ENSMUSG00185001764
 protein coding gene Chr1:131786615-131826686 (-)
FVB/NJ ENSMUSG00205021095
 protein coding gene Chr1:126744357-126769755 (-)
JF1/MsJ ENSUMUG00000001016
 protein coding gene Chr1:130959019-131005469 (-)
LP/J ENSMUSG00230000860
 protein coding gene Chr1:131365992-131406068 (-)
NOD/ShiLtJ ENSMUSG00190039056
 protein coding gene Chr1:127433813-127459207 (-)
NZO/HlLtJ ENSMUSG00225016065
 protein coding gene Chr1:135102769-135128164 (-)
PWK/PhJ ENSLUMG00010023486
 protein coding gene Chr1:126565030-126611270 (-)
SPRET/EiJ ENSMSPG00010041880
 protein coding gene Chr1:129367133-129395709 (-)
WSB/EiJ ENSIUOG00005047310
 protein coding gene Chr1:127171282-127211357 (-)



Homology
more
  • Human Ortholog
    PFKFB2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PFKFB2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  • Synonyms
    PFK-2/FBPase-2
  • Links
    NCBI Gene ID: 5208
    UniProt: O60825

  • Chr Location
    1q32.1; chr1:207034366-207081243 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous expression of a phosphorylation-deficient mutant in alveolar type II (AT2) cells leads to lung fibrosis, reduced lung compliance and forced vital lung capacity and reduced number of alveolar type I (AT1) cells after lung injury. Homozygous expression of a phosphomimetic mutant in AT2 cells leads to reduced morbidity after lung injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    697
  • Tissues
    97
  • cDNA Data
    59
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026409 Ensembl Gene Model | MGI Sequence Detail 40072 C57BL/6J ±  kb
    transcript ENSMUST00000191347 Ensembl | MGI Sequence Detail 1759 Not Applicable  
    polypeptide ENSMUSP00000140698 Ensembl | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 59
      Primer pair 2
      Other 1
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36392, MGI:1923175
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:373032 Harold KM, et al., Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart. J Am Heart Assoc. 2024 Apr 2;13(7):e033676
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory