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Ilrun Gene Detail
Summary
  • Symbol
    Ilrun
  • Name
    inflammation and lipid regulator with UBA-like and NBR1-like domains
  • Synonyms
    D17Wsu92e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106281
    NCBI Gene: 224647
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27970206-28039516 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.59 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    641 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106281
 protein coding gene Chr17:27970206-28039622 (-)
129S1/SvImJ ENSMUSG00200051376
 protein coding gene Chr17:23627797-23697114 (-)
A/J ENSMUSG00195053180
 protein coding gene Chr17:24444524-24513591 (-)
AKR/J ENSMUSG00220051271
 protein coding gene Chr17:23492165-23561231 (-)
BALB/cJ ENSMUSG00180032500
 protein coding gene Chr17:23924670-23993990 (-)
C3H/HeJ ENSMUSG00175050359
 protein coding gene Chr17:23480624-23549690 (-)
C57BL/6NJ ENSMUSG00215053576
 protein coding gene Chr17:23480838-23550250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021307
 protein coding gene Chr17:23602447-23670449 (-)
CAST/EiJ ENSTCUG00005041202
 protein coding gene Chr17:24214033-24287660 (-)
CBA/J ENSMUSG00210040858
 protein coding gene Chr17:23319081-23388150 (-)
DBA/2J ENSMUSG00185052027
 protein coding gene Chr17:25534029-25603096 (-)
FVB/NJ ENSMUSG00205045269
 protein coding gene Chr17:23795527-23864599 (-)
JF1/MsJ ENSUMUG00000043536
 protein coding gene Chr17:24990502-25058848 (-)
LP/J ENSMUSG00230054489
 protein coding gene Chr17:27053652-27122965 (-)
NOD/ShiLtJ ENSMUSG00190050098
 protein coding gene Chr17:23428295-23497712 (-)
NZO/HlLtJ ENSMUSG00225052099
 protein coding gene Chr17:29022212-29091625 (-)
PWK/PhJ ENSLUMG00010038496
 protein coding gene Chr17:22919137-22988427 (-)
SPRET/EiJ ENSMSPG00010036934
 protein coding gene Chr17:24212918-24282415 (-)
WSB/EiJ ENSIUOG00005050321
 protein coding gene Chr17:24186698-24256528 (-)



Homology
more
  • Human Ortholog
    ILRUN, inflammation and lipid regulator with UBA-like and NBR1-like domains
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ILRUN, inflammation and lipid regulator with UBA-like and NBR1-like domains
  • Synonyms
    C6orf106, dJ391O22.4, FP852
  • Links
    NCBI Gene ID: 64771
    UniProt: Q9H6K1

  • Chr Location
    6p21.31; chr6:34587288-34696881 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased plasma HDL cholesterol levels due to reduced liver lipoprotein production, decreased circulating LDL cholesterol and phospholipid levels, reduced VLDL-triglyceride secretion, and impaired glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Tissues
    41
  • cDNA Data
    206
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224647 NCBI Gene Model | MGI Sequence Detail 69311 C57BL/6J ±  kb
    transcript NM_001033279 RefSeq | MGI Sequence Detail 3812 ZRU/MplStud  
    polypeptide Q3TT38 UniProt | EBI | MGI Sequence Detail 291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 208
      Genomic 1
      cDNA 206
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33973, MGI:2146985, MGI:2147136, MGI:6279317
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory