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Hgs Gene Detail
Summary
  • Symbol
    Hgs
  • Name
    HGF-regulated tyrosine kinase substrate
  • Synonyms
    Hrs, tn
  • Feature Type
    protein coding gene
  • IDs
    MGI:104681
    NCBI Gene: 15239
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120358461-120374805 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    555 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104681
 protein coding gene Chr11:120358431-120374810 (+)
129S1/SvImJ ENSMUSG00200050261
 protein coding gene Chr11:117721828-117738374 (+)
A/J ENSMUSG00195027037
 protein coding gene Chr11:117396879-117413435 (+)
AKR/J ENSMUSG00220025166
 protein coding gene Chr11:117547285-117563842 (+)
BALB/cJ ENSMUSG00180051881
 protein coding gene Chr11:117689664-117706220 (+)
C3H/HeJ ENSMUSG00175036286
 protein coding gene Chr11:117647475-117664031 (+)
C57BL/6NJ ENSMUSG00215043155
 protein coding gene Chr11:117217393-117233948 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017521
 protein coding gene Chr11:116364296-116380423 (+)
CAST/EiJ ENSTCUG00005027934
 protein coding gene Chr11:117077200-117093458 (+)
CBA/J ENSMUSG00210047021
 protein coding gene Chr11:117361524-117378075 (+)
DBA/2J ENSMUSG00185021578
 protein coding gene Chr11:117674660-117691208 (+)
FVB/NJ ENSMUSG00205045302
 protein coding gene Chr11:117522387-117538936 (+)
JF1/MsJ ENSUMUG00000046709
 protein coding gene Chr11:117967941-117984682 (+)
LP/J ENSMUSG00230046401
 protein coding gene Chr11:118740429-118756987 (+)
NOD/ShiLtJ ENSMUSG00190042986
 protein coding gene Chr11:117745794-117762339 (+)
NZO/HlLtJ ENSMUSG00225050233
 protein coding gene Chr11:120889546-120906092 (+)
PWK/PhJ ENSLUMG00010021197
 protein coding gene Chr11:117485757-117502241 (+)
SPRET/EiJ ENSMSPG00010037261
 protein coding gene Chr11:118056658-118072844 (+)
WSB/EiJ ENSIUOG00005046989
 protein coding gene Chr11:117480272-117496789 (+)



Homology
more
  • Human Ortholog
    HGS, hepatocyte growth factor-regulated tyrosine kinase substrate
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HGS, hepatocyte growth factor-regulated tyrosine kinase substrate
  • Synonyms
    HRS
  • Links
    NCBI Gene ID: 9146
    UniProt: O14964

  • Chr Location
    17q25.3; chr17:81683326-81703138 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 8 alleles in 9 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality during organogenesis with decreased size and no embryo turning. In addition, one allele shows cardia bifida, no foregut formation, failure of chorioallantoic fusion and neural tube,somite and allantois defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    76
  • cDNA Data
    127
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025793 Ensembl Gene Model | MGI Sequence Detail 16345 C57BL/6J ±  kb
    transcript ENSMUST00000106203 Ensembl | MGI Sequence Detail 2903 Not Applicable  
    polypeptide ENSMUSP00000101809 Ensembl | MGI Sequence Detail 776 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008536 hepatocyte growth factor-regulated tyrosine kinase substrate
      (term hierarchy)
    • InterPro Domains
      IPR008942 ENTH/VHS
      IPR000306 FYVE zinc finger
      IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain
      IPR017073 Hepatocyte growth factor-regulated tyrosine kinase substrate/VPS27
      IPR003903 Ubiquitin interacting motif
      IPR002014 VHS domain
      IPR011011 Zinc finger, FYVE/PHD-type
      IPR017455 Zinc finger, FYVE-related
      IPR013083 Zinc finger, RING/FYVE/PHD-type
    • GlyGen
      Q99LI8 10 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 128
      Primer pair 3
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15148, MGD-MRK-27044, MGI:98778
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 9
      Gene Ontology 16
      Phenotypes 32
    • Earliest
      J:5025 Meier H, The neuropathy of teetering, a neurological mutation in the mouse. Arch Neurol. 1967 Jan;16(1):59-66
    • Latest
      J:361729 Yang G, et al., Identification of the metaphyseal skeletal stem cell building trabecular bone. Sci Adv. 2024 Feb 23;10(8):eadl2238
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory