About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hgs
HGF-regulated tyrosine kinase substrate
MGI:104681
66 phenotypes from 8 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
HgsTg(Tyr)2400A-1Ove/HgsTg(Tyr)2400A-1Ove
FVB/N-HgsTg(Tyr)2400A-1Ove
embryonic lethality between implantation and somite formation J:175597
Hgstm1a(EUCOMM)Wtsi/Hgs+
Not Specified
abnormal coping response J:165965
Hgstm1b(EUCOMM)Wtsi/Hgstm1b(EUCOMM)Wtsi
C57BL/6N-Hgstm1b(EUCOMM)Wtsi/Ieg
preweaning lethality, complete penetrance J:211773
Hgstm1Sor/Hgstm1Sor
either: 129/Sv-Hgstm1Sor or B6.129-Hgstm1Sor or (involves: 129/Sv * 129S4/SvJae * C57BL/6J)
abnormal embryonic tissue morphology J:55580
abnormal extraembryonic tissue morphology J:55580
abnormal rostral-caudal axis patterning J:55580
abnormal somite development J:55580
absent foregut J:55580
cardia bifida J:55580
decreased embryo size J:55580
dilated allantois J:55580
embryonic lethality during organogenesis, complete penetrance J:55580
failure of chorioallantoic fusion J:55580
failure of initiation of embryo turning J:55580
open neural tube J:55580
wavy neural tube J:55580
Hgstm1Sug/Hgstm1Sug
involves: 129S4/SvJae * C57BL/6J
decreased embryo size J:65990
embryonic lethality, complete penetrance J:65990
failure of initiation of embryo turning J:65990
Hgstm1Tkh/Hgstm1Tkh
involves: 129S4/SvJae * C57BL/6
abnormal cell physiology J:97764
embryonic lethality during organogenesis, complete penetrance J:97764
Hgstm2Tkh/Hgstm2Tkh
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA * SJL
abnormal hippocampus pyramidal cell morphology J:141391
behavioral despair J:141391
decreased vertical activity J:141391
impaired passive avoidance behavior J:141391
increased neuron apoptosis J:141391
infertility J:141391
postnatal growth retardation J:141391
slow postnatal weight gain J:141391
Hgstn/Hgstn
B6.C3-Hgstn
abnormal axon morphology J:5025
abnormal brain development J:5025
abnormal cerebellar cortex morphology J:5025
abnormal CNS glial cell morphology J:5025
abnormal medulla oblongata morphology J:5025
abnormal motor coordination/balance J:5025
abnormal myelin sheath morphology J:5025
abnormal resting posture J:5025
abnormal spinal cord grey matter morphology J:5025
abnormal spinal cord white matter morphology J:5025
abnormal spinal nerve morphology J:5025
abnormal vertebral column morphology J:5025
abnormal vertebral spinous process morphology J:5025
axonal dystrophy J:5025
cachexia J:5025
decreased body height J:5025
decreased body size J:5025
decreased corticospinal tract size J:5025
decreased hindbrain size J:5025
decreased midbrain size J:5025
decreased neuron number J:5025
decreased pons size J:5025
decreased spinal cord size J:5025
decreased trabecular bone thickness J:5025
impaired balance J:5025
impaired swimming J:5025
increased stereotypic behavior J:5025
jerky movement J:5025
muscular atrophy J:5025
opisthotonus J:5025
paralysis J:5025
postnatal growth retardation J:5025
premature death J:5025
Purkinje cell degeneration J:5025
short vertebral body J:5025
small cerebellum J:5025
thin cerebellar granule layer J:5025
Hgstn/Hgstn
C3H/HeJ-Hgstn
abnormal posture J:13411
abnormal stationary movement J:13411
bradykinesia J:13411
normal hearing/vestibular/ear phenotype J:13411
premature death J:13411

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory