Hgs^tm1Tkh
Targeted Allele Detail

Summary

• Symbol: Hgs^tm1Tkh
• Name: HGF-regulated tyrosine kinase substrate; targeted mutation 1, Nobuyuki Tanaka
• MGI ID: MGI:3576931
• Synonyms: hrs^floxP
• Gene: Hgs Location: Chr11:120358461-120374805 bp, + strand Genetic Position: Chr11, 84.16 cM
• Alliance: Hgs^tm1Tkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97764
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 5 and a neo with a 3' loxP site was inserted into intron 6, allowing the conditional excision of the sequence encoding the VHS domain. (J:97764)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgs Mutation: 38 strains or lines available

References

• Original: J:97764 Kobayashi H, et al., Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. J Biol Chem. 2005 Mar 18;280(11):10468-77
• All: 1 reference(s)