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Hcls1 Gene Detail
Summary
  • Symbol
    Hcls1
  • Name
    hematopoietic cell specific Lyn substrate 1
  • Synonyms
    HS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104568
    NCBI Gene: 15163
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36755345-36783574 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.30 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    708 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104568
 protein coding gene Chr16:36755345-36783576 (+)
129S1/SvImJ ENSMUSG00200027387
 protein coding gene Chr16:33691145-33719373 (+)
A/J ENSMUSG00195010355
 protein coding gene Chr16:33237586-33265808 (+)
AKR/J ENSMUSG00220028621
 protein coding gene Chr16:33615225-33643446 (+)
BALB/cJ ENSMUSG00180012839
 protein coding gene Chr16:33453200-33481420 (+)
C3H/HeJ ENSMUSG00175031516
 protein coding gene Chr16:33673571-33701787 (+)
C57BL/6NJ ENSMUSG00215018925
 protein coding gene Chr16:33526739-33554965 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020723
 protein coding gene Chr16:33979893-34008215 (+)
CAST/EiJ ENSTCUG00005030269
 protein coding gene Chr16:33945693-33973997 (+)
CBA/J ENSMUSG00210026639
 protein coding gene Chr16:33730651-33758867 (+)
DBA/2J ENSMUSG00185022891
 protein coding gene Chr16:33633682-33661902 (+)
FVB/NJ ENSMUSG00205013783
 protein coding gene Chr16:33590604-33618834 (+)
JF1/MsJ ENSUMUG00000018076
 protein coding gene Chr16:33854532-33882672 (+)
LP/J ENSMUSG00230025610
 protein coding gene Chr16:36205879-36234092 (+)
NOD/ShiLtJ ENSMUSG00190022350
 protein coding gene Chr16:33752031-33780259 (+)
NZO/HlLtJ ENSMUSG00225037728
 protein coding gene Chr16:39305238-39333453 (+)
PWK/PhJ ENSLUMG00010029262
 protein coding gene Chr16:33762338-33790506 (+)
SPRET/EiJ ENSMSPG00010016331
 protein coding gene Chr16:33734352-33762579 (+)
WSB/EiJ ENSIUOG00005024009
 protein coding gene Chr16:33803234-33831533 (+)



Homology
more
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCLS1, hematopoietic cell-specific Lyn substrate 1
  • Synonyms
    CTTNL, HS1, lckBP1, p75
  • Links
    NCBI Gene ID: 3059
    UniProt: P14317

  • Chr Location
    3q13.33; chr3:121631399-121660927 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    1
  • cDNA Data
    43
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022831 Ensembl Gene Model | MGI Sequence Detail 28230 C57BL/6J ±  kb
    transcript ENSMUST00000023531 Ensembl | MGI Sequence Detail 2016 Not Applicable  
    polypeptide ENSMUSP00000023531 Ensembl | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 4
      cDNA 43

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26002, MGI:2146629
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:16376 Fukamachi H, et al., Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol. 1994 Jan 15;152(2):642-52
    • Latest
      J:391209 Russo L, et al., HS1 loss drives cytoskeletal dysregulation and reduces sensitivity to BTK inhibition in chronic lymphocytic leukemia. J Leukoc Biol. 2026 Jul 31;118(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory