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Cdk5r1 Gene Detail
Summary
  • Symbol
    Cdk5r1
  • Name
    cyclin dependent kinase 5, regulatory subunit 1
  • Synonyms
    D11Bwg0379e, p25, p35
  • Feature Type
    protein coding gene
  • IDs
    MGI:101764
    NCBI Gene: 12569
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:80367849-80372010 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101764
 protein coding gene Chr11:80367849-80372010 (+)
129S1/SvImJ ENSMUSG00200049559
 protein coding gene Chr11:77489010-77493171 (+)
A/J ENSMUSG00195042290
 protein coding gene Chr11:77368019-77372181 (+)
AKR/J ENSMUSG00220043753
 protein coding gene Chr11:77589984-77594146 (+)
BALB/cJ ENSMUSG00180035730
 protein coding gene Chr11:77549110-77553283 (+)
C3H/HeJ ENSMUSG00175032936
 protein coding gene Chr11:77532841-77537442 (+)
C57BL/6NJ ENSMUSG00215028151
 protein coding gene Chr11:77149941-77154102 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016840
 protein coding gene Chr11:75437392-75441592 (+)
CAST/EiJ ENSTCUG00005043937
 protein coding gene Chr11:77047275-77051455 (+)
CBA/J ENSMUSG00210041584
 protein coding gene Chr11:77356394-77360555 (+)
DBA/2J ENSMUSG00185030589
 protein coding gene Chr11:77614307-77618468 (+)
FVB/NJ ENSMUSG00205033073
 protein coding gene Chr11:77430488-77434649 (+)
JF1/MsJ ENSUMUG00000051201
 protein coding gene Chr11:78006911-78011074 (+)
LP/J ENSMUSG00230044673
 protein coding gene Chr11:78644589-78648750 (+)
NOD/ShiLtJ ENSMUSG00190032366
 protein coding gene Chr11:77661240-77665402 (+)
NZO/HlLtJ ENSMUSG00225038952
 protein coding gene Chr11:80812134-80816295 (+)
PWK/PhJ ENSLUMG00010019313
 protein coding gene Chr11:77528121-77532284 (+)
SPRET/EiJ ENSMSPG00010031920
 protein coding gene Chr11:77908127-77912292 (+)
WSB/EiJ ENSIUOG00005033803
 protein coding gene Chr11:77495850-77500031 (+)



Homology
more
  • Human Ortholog
    CDK5R1, cyclin dependent kinase 5 regulatory subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK5R1, cyclin dependent kinase 5 regulatory subunit 1
  • Synonyms
    CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
  • Links
    NCBI Gene ID: 8851
    UniProt: Q15078

  • Chr Location
    17q11.2; chr17:32486156-32491253 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdk5r1 mouse models; 1 with human CDK5R1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 5 alleles in 7 genetic backgrounds
    24 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of the gene results in structural abnormalities of the brain such as a small corpus callosum and delaminated cerebral cortex. Mice show hyperactivity and decreased locomotion in response to stimulants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    134
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    890
  • Tissues
    173
  • cDNA Data
    17
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12569 NCBI Gene Model | MGI Sequence Detail 4162 C57BL/6J ±  kb
    transcript NM_009871 RefSeq | MGI Sequence Detail 4139 C57BL/6  
    polypeptide P61809 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 3
      cDNA 18
      Primer pair 4
      Other 5
      Antibodies 7

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-18570, MGD-MRK-34066, MGI:106373
    References
    more
    • Summaries
      All 223
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 29
      Phenotypes 76
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:387037 Fu K, et al., CDK5-mediated hyperphosphorylation of Tau217 impairs neuronal synaptic structure and exacerbates cognitive impairment in Alzheimer's disease. Transl Psychiatry. 2025 Aug 21;15(1):302
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory