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Mapping Data
  • Experiment
    TEXT-Physical Mapping
  • Chromosome
  • Reference
    J:72911 Murdoch JN, et al., Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet. 2001 Oct 15;10(22):2593-601
  • ID
GeneAlleleAssay TypeDescription
D1Mit113 sequence analysis
Cd84 sequence analysis
Vangl2 sequence analysis
340L6T7 sequence analysis
Nhlh1 sequence analysis
D1Sta2 sequence analysis
Ncstn sequence analysis
Copa sequence analysis
Pex19 sequence analysis
Timm23 sequence analysis
Dcaf8 sequence analysis
Pea15a sequence analysis
Casq1 sequence analysis
446G11T7 sequence analysis
D1Sta3 sequence analysis
Atp1a4 sequence analysis
423N13T7 sequence analysis
378C5T7 sequence analysis
Atp1a2 sequence analysis
  • Experiment
    The authors used previous genetic and physical mapping studies to refine the Lp interval to a critical region of ~ 450kb. The complete transcript map was developed using a combination of computational methods. The order of markers was determined to be: D11Mit113 - Cd84 - Vangl2 - 340L6T7 - Nhlh1 - D1Sta2 - Ncstn - Copa - Pex19 - Timm23 - D1Ucla4 - Pea15 - Casq1 - 446G11T7 - D1Sta3 - Atp1a4 - 423N13T7 - 378C5T7 - Atp1a2. Comparative sequence analysis identified a G -> A transition in exon 8 of the Ltap gene. This substitution was unique to the Lp mutant allele and was not seen in 8 other mouse strains. The substitution caused a change from serine to asparagine and this is beleived to disrupt the normal function of the Vangl2 protein.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
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