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Timm23 Gene Detail
Summary
  • Symbol
    Timm23
  • Name
    translocase of inner mitochondrial membrane 23
  • Synonyms
    MGC:46821, Tim23
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858317
    NCBI Gene: 53600
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31902123-31923848 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    637 from dbSNP Build 142
  • Strain Annotations
    30
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858317
 protein coding gene Chr14:31902119-31923855 (-)
129S1/SvImJ ENSMUSG00200024979
 protein coding gene Chr10:55895331-55896486 (+)
129S1/SvImJ ENSMUSG00200037807
 protein coding gene Chr14:23728292-23750045 (-)
A/J ENSMUSG00195012253
 protein coding gene Chr14:24799628-24821365 (-)
A/J ENSMUSG00195025254
 protein coding gene Chr10:56195020-56196173 (+)
AKR/J ENSMUSG00220040491
 protein coding gene Chr10:55899856-55901008 (+)
AKR/J ENSMUSG00220034234
 protein coding gene Chr14:23911958-23933697 (-)
BALB/cJ ENSMUSG00180026908
 protein coding gene Chr14:23888163-23909898 (-)
BALB/cJ ENSMUSG00180026766
 protein coding gene Chr10:56250052-56251204 (+)
C3H/HeJ ENSMUSG00175025148
 protein coding gene Chr10:56102624-56103779 (+)
C3H/HeJ ENSMUSG00175033505
 protein coding gene Chr14:23955379-23977115 (-)
C57BL/6NJ ENSMUSG00215042695
 protein coding gene Chr1:168929063-168930187 (-)
C57BL/6NJ ENSMUSG00215021764
 protein coding gene Chr10:55848185-55849337 (+)
C57BL/6NJ ENSMUSG00215018443
 protein coding gene Chr14:24193864-24215602 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019088
 protein coding gene Chr14:24508987-24530674 (-)
CAST/EiJ ENSTCUG00005024098
 protein coding gene Chr14:24034105-24056026 (-)
CBA/J ENSMUSG00210031427
 protein coding gene Chr10:55980979-55982131 (+)
CBA/J ENSMUSG00210041252
 protein coding gene Chr14:24198269-24220005 (-)
DBA/2J ENSMUSG00185039658
 protein coding gene Chr14:28467618-28489354 (-)
DBA/2J ENSMUSG00185031719
 protein coding gene Chr14:60217142-60218073 (+)
FVB/NJ ENSMUSG00205017966
 protein coding gene Chr10:56000027-56001179 (+)
FVB/NJ ENSMUSG00205033542
 protein coding gene Chr14:24057871-24079603 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230022900
 protein coding gene Chr10:58130953-58132108 (+)
LP/J ENSMUSG00230033668
 protein coding gene Chr14:35752294-35774045 (-)
NOD/ShiLtJ ENSMUSG00190017984
 protein coding gene Chr14:24211881-24233617 (-)
NOD/ShiLtJ ENSMUSG00190035071
 protein coding gene Chr10:56313546-56314698 (+)
NZO/HlLtJ ENSMUSG00225036481
 protein coding gene Chr14:30086579-30108315 (-)
NZO/HlLtJ ENSMUSG00225044658
 protein coding gene Chr10:62411906-62413052 (+)
PWK/PhJ ENSLUMG00010021135
 protein coding gene Chr14:12323464-12345488 (-)
SPRET/EiJ ENSMSPG00010035977
 protein coding gene Chr14:25880783-25903413 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TIMM23, translocase of inner mitochondrial membrane 23
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMM23, translocase of inner mitochondrial membrane 23
  • Synonyms
    TIM23
  • Links
    NCBI Gene ID: 100287932
    UniProt: O14925

  • Chr Location
    chr10:45972486-46004338 (+)  GRCh38
  • Human Ortholog
    TIMM23B, translocase of inner mitochondrial membrane 23 homolog B
  • Links
    NCBI Gene ID: 100652748
    UniProt: Q5SRD1

  • Chr Location
    chr10:49942049-49977625 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die prior to E3.5. Mice heterogygous for this allele exhibit background sensitive premature aging and increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    22
  • cDNA Data
    9
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53600 NCBI Gene Model | MGI Sequence Detail 21726 C57BL/6J ±  kb
    transcript NM_016897 RefSeq | MGI Sequence Detail 1162 C57BL/6  
    polypeptide Q9WTQ8 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016347 mitochondrial import inner membrane translocase subunit Tim23
      (term hierarchy)
    • InterPro Domains
      IPR005681 Mitochondrial inner membrane translocase complex, subunit Tim23
      IPR045238 Tim23-like
    • GlyGen
      Q9WTQ8 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 10
      Primer pair 1
      Antibodies 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 9
    • Earliest
      J:63697 Underhill DA, et al., Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation. Mamm Genome. 2000 Aug;11(8):633-8
    • Latest
      J:307067 Jiao H, et al., Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell. 2021 May 27;184(11):2896-2910.e13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory