Dcaf8 MGI Mouse Gene Detail - MGI:91860 - DDB1 and CUL4 associated factor 8

Symbol

Dcaf8
Name

DDB1 and CUL4 associated factor 8
Synonyms

D1Dau35e, D1Ucla4, H326, Wdr42a

Feature Type

protein coding gene
IDs

MGI:91860
NCBI Gene: 98193
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:171975574-172023960 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.54 cM
Mapping Data

10 experiments

SNPs within 2kb

338 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_91860	protein coding gene	Chr1:171975574-172024572 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016779	protein coding gene	Chr1:178002331-178054816 (+)
A/J	MGP_AJ_G0016758	protein coding gene	Chr1:170714816-170765262 (+)
AKR/J	MGP_AKRJ_G0016724	protein coding gene	Chr1:175875064-175927493 (+)
BALB/cJ	MGP_BALBcJ_G0016719	protein coding gene	Chr1:171262824-171312017 (+)
C3H/HeJ	MGP_C3HHeJ_G0016543	protein coding gene	Chr1:176450989-176500096 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017181	protein coding gene	Chr1:183907297-183962904 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014887	protein coding gene	Chr1:162421199-162470178 (+)
CAST/EiJ	MGP_CASTEiJ_G0016123	protein coding gene	Chr1:175809682-175860345 (+)
CBA/J	MGP_CBAJ_G0016517	protein coding gene	Chr1:190456380-190516160 (+)
DBA/2J	MGP_DBA2J_G0016624	protein coding gene	Chr1:169655004-169702124 (+)
FVB/NJ	MGP_FVBNJ_G0016621	protein coding gene	Chr1:167909965-167958261 (+)
LP/J	MGP_LPJ_G0016695	protein coding gene	Chr1:179092885-179146530 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016648	protein coding gene	Chr1:197709617-197762130 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017217	protein coding gene	Chr1:175742849-175795000 (+)
PWK/PhJ	MGP_PWKPhJ_G0015909	protein coding gene	Chr1:169027036-169077120 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015691	protein coding gene	Chr1:174687959-174745792 (+)
WSB/EiJ	MGP_WSBEiJ_G0016185	protein coding gene	Chr1:175894957-175950215 (+)

Human Ortholog

DCAF8, DDB1 and CUL4 associated factor 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF8, DDB1 and CUL4 associated factor 8
Synonyms

GAN2, H326, WDR42A
Links

HGNC:24891

NCBI Gene ID: 50717

neXtProt AC: NX_Q5TAQ9

UniProt: Q5TAQ9
Chr Location

1q23.2; chr1:160215715-160262549 (-) GRCh38

MGI Vertebrate Homology

Dcaf8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCAF8
Gene Tree

Dcaf8

Diseases

1 with human DCAF8 associations

				Human Disease	Mouse Models
				giant axonal neuropathy 2 IDs giant axonal neuropathy 2 DOID:0090069 OMIM:610100

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

69
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

64
Genomic Mutations

2 involving Dcaf8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

125 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

16
cDNA Data

162
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf8

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All Sequences

97
RefSeq

22
UniProt

3
CCDS

CCDS15509.1

Ensembl

ENSMUSG00000026554 (Evidence)
NCBI Gene

98193

			Length	Strain/Species	Flank
genomic	98193	NCBI Gene Model \| MGI Sequence Detail	48387	C57BL/6J	± kb
transcript	NM_001421210	RefSeq \| MGI Sequence Detail	4642	ZRU/MplStud
polypeptide	Q8N7N5	UniProt \| EBI \| MGI Sequence Detail	591	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029378 DDB1- and CUL4-associated factor 8

(term hierarchy)
InterPro Domains

IPR045151 DDB1- and CUL4-associated factor 8-like

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 196

Genomic 25

cDNA 166

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-5719, MGI:1347003, MGI:1888988, MGI:2138088, MGI:2138099, MGI:2138429, MGI:2138650

Summaries

All 50

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 12
Earliest

J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
Latest

J:307635 Brandao R, et al., ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. FEBS Open Bio. 2021 Jun;11(6):1579-1592

TSS for Dcaf8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10170	Chr1:171975604-171975615 (+)	36 bp
Tssr10171	Chr1:171975625-171975661 (+)	69 bp
Tssr10172	Chr1:171975665-171975670 (+)	94 bp
Tssr10173	Chr1:171975677-171975743 (+)	136 bp
Tssr10174	Chr1:171985099-171985101 (+)	9,526 bp
Tssr10175	Chr1:171993090-171993099 (+)	17,521 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23