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Phenotype Images associated with this Allele
Nomenclature
Symbol: Gcn1em1(IMPC)J
Name: GCN1 activator of EIF2AK4; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6477990
Synonyms: Gcn1-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Gcn1em1(IMPC)J/Gcn1em1(IMPC)J embryos are small and growth delayed. E9.5 embryos remain unturned or display incomplete turning, show abnormal yolk sac vascularization, and abnormal head shape and cranial neural tube closure. E10.5 embryos display turning defects, severe cardiac defects, open cranial neural tube and more than 50% lethality.Gcn1em1(IMPC)J/Gcn1em1(IMPC)JC57BL/6NJ-Gcn1em1(IMPC)J/Mmjax
Placental abnormalities in Gcn1em1(IMPC)J/Gcn1em1(IMPC)J embryos, with impaired chorioallantoic attachment and branching and multiple labyrinth zone defects.Gcn1em1(IMPC)J/Gcn1em1(IMPC)JC57BL/6NJ-Gcn1em1(IMPC)J/Mmjax
E8.5 Gcn1em1(IMPC)J/Gcn1em1(IMPC)J embryos show embryonic growth delay despite formation of all 3 germ layers.Gcn1em1(IMPC)J/Gcn1em1(IMPC)JC57BL/6NJ-Gcn1em1(IMPC)J/Mmjax
Although grossly abnormal, Gcn1em1(IMPC)J/Gcn1em1(IMPC)J embryos form all 3 germ layers and initiate cardiac development and gut tube closure at E9.5.Gcn1em1(IMPC)J/Gcn1em1(IMPC)JC57BL/6NJ-Gcn1em1(IMPC)J/Mmjax
E7.5 Gcn1em1(IMPC)J/Gcn1em1(IMPC)J (-/-) embryos are always the smallest in their litters.Gcn1em1(IMPC)J/Gcn1em1(IMPC)JC57BL/6NJ-Gcn1em1(IMPC)J/Mmjax
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory