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Phenotype Images associated with this Allele
Nomenclature
Symbol: Gjc2tm2.1Kwi
Name: gap junction protein, gamma 2; targeted mutation 2.1, Klaus Willecke
MGI ID: MGI:5140116
Synonyms: Cx47M282T
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Toluidine blue/pyronin g stained semi-thin sections reveal cystic spaces in white matter of Gjc2tm2.1Kwi/Gjc2tm2.1Kwi miceGjc2tm2.1Kwi/Gjc2tm2.1Kwiinvolves: C57BL/6 * SJL
Disturbed myelin basic protein (MBP) expression accompanied by astrogliosis and microglial activation in juvenile Gjc2tm2.1Kwi/Gjc2tm2.1Kwi, Gjc2tm2.1Kwi/Gjc2+, and Gjc2tm1(EGFP)Kwi/Gjc2tm1(EGFP)Kwi miceGjc2tm1(EGFP)Kwi/Gjc2tm1(EGFP)Kwiinvolves: 129P2/OlaHsd * C57BL/6
Gjc2tm2.1Kwi/Gjc2tm2.1Kwiinvolves: C57BL/6 * SJL
Gjc2tm2.1Kwi/Gjc2+involves: C57BL/6 * SJL
Insufficient myelination resulting from loss of Gjc2 (Cx47) function is largely compensated in adult Gjc2tm2.1Kwi/Gjc2+ and Gjc2tm2.1Kwi/Gjc2tm2.1Kwi miceGjc2tm2.1Kwi/Gjc2tm2.1Kwiinvolves: C57BL/6 * SJL
Gjb1tm1Kwi/Y
Gjc2tm2.1Kwi/Gjc2tm2.1Kwi		involves: 129S4/SvJae * C57BL/6 * SJL
A variable number of blood vessels predominantly in the hippocampal region of Gjc2tm2.1Kwi/Gjc2tm2.1Kwi mice feature perivascular glia being filled with basophilic material or undergoing conspicuous destructionGjc2tm2.1Kwi/Gjc2tm2.1Kwiinvolves: C57BL/6 * SJL
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory