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Targeted Allele Detail
Symbol: Gjb1tm1Kwi
Name: gap junction protein, beta 1; targeted mutation 1, Klaus Willecke
MGI ID: MGI:1857927
Synonyms: Cx32-
Gene: Gjb1  Location: ChrX:100419984-100429235 bp, + strand  Genetic Position: ChrX, 44.06 cM, cytoband D-F4
Alliance: Gjb1tm1Kwi page
Germline Transmission:  Earliest citation of germline transmission: J:36146
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 2 of the gene, resulting in a stop codon 90 nucleotides after the translational start and a new start codon 15 base pairs further downstream. Northern blots of total liver RNA from homozygous mutant mice showed no detectable transcript for the gene. (J:36146)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Gjb1tm1Kwi
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjb1 Mutation:  32 strains or lines available
Original:  J:36146 Nelles E, et al., Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9565-70
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory