About   Help   FAQ
Targeted Allele Detail
Symbol: Gjc2tm1(EGFP)Kwi
Name: gap junction protein, gamma 2; targeted mutation 1, Klaus Willecke
MGI ID: MGI:2664941
Synonyms: Cx47EGFP
Gene: Gjc2  Location: Chr11:59066394-59074039 bp, - strand  Genetic Position: Chr11, 37.05 cM
Alliance: Gjc2tm1(EGFP)Kwi page
Disturbed myelin basic protein (MBP) expression accompanied by astrogliosis and microglial activation in juvenile Gjc2tm2.1Kwi/Gjc2tm2.1Kwi, Gjc2tm2.1Kwi/Gjc2+, and Gjc2tm1(EGFP)Kwi/Gjc2tm1(EGFP)Kwi mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:83885
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsEGFP-1 was inserted, beginning with its ATG start codon, "in frame" after the first 7 codons of the gene followed (in antisense orientation) by HPRT driven by the mouse PGK promotor. This insertion replaced the rest of the gene and 560 bp of the 3' untranslated region. Homozygous mutant mice failed to express target gene mRNA but did express EGFP mRNA. (J:83885)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjc2 Mutation:  21 strains or lines available
Original:  J:83885 Odermatt B, et al., Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS. J Neurosci. 2003 Jun 1;23(11):4549-59
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.23
The Jackson Laboratory