Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	SOD2	HGNC:11180 (HGNC) 6648 (Entrez Gene) 147460 (OMIM) SOD2 (Alliance of Genome Resources)	Chr6 q25.3	Chr6:159669069-159762529 (-) GRCh38	acute myeloid leukemia alcoholic liver cirrhosis Alzheimer's disease asthma bilirubin metabolic disorder breast cancer cardiomyopathy carotid artery disease diabetic angiopathy dilated cardiomyopathy hepatocellular carcinoma hypertension inclusion body myositis infectious mononucleosis Kuhnt-Junius degeneration Leber hereditary optic neuropathy liver cirrhosis lung cancer metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease multiple myeloma neuronal ceroid lipofuscinosis optic neuritis osteoporosis ovarian cancer pancreatic cancer polyneuropathy primary open angle glaucoma pseudoxanthoma elasticum reactive arthritis stomach cancer systemic lupus erythematosus type 1 diabetes mellitus type 2 diabetes mellitus vitiligo	P04179 (UniProt | EBI) NM_001322816 (RefSeq)
mouse	Sod2	MGI:98352 (MGI) 20656 (Entrez Gene) Gene Tree Sod2 (Alliance of Genome Resources)	Chr17 8.75 cM	Chr17:13226726-13237006 (+) GRCm39	amyotrophic lateral sclerosis type 1 Canavan disease congestive heart failure dilated cardiomyopathy Leigh disease	20656 (NCBI Gene Model) P09671 (UniProt | EBI) NM_013671 (RefSeq)
rat	Sod2	RGD:3732 (Rat Genome Database) 24787 (Entrez Gene) Sod2 (Alliance of Genome Resources)	Chr1 q11			P07895 (UniProt | EBI) NM_017051 (RefSeq)
zebrafish	sod2	ZDB-GENE-030131-7742 (Zebrafish Model Organism Database) 335799 (Entrez Gene) sod2 (Alliance of Genome Resources)	Chr20			NP_956270 (RefSeq) NM_199976 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.