Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZIC5
  • Mouse genes Zic5
  • Rat genes Zic5
  • Zfish genes zic5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zic5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Zic5	IDA		Mouse	PMID:15465018
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Zic5	IDA		Mouse	MGI:MGI:3056015|PMID:15465018
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Zic5	IDA		Mouse	PMID:18298960
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ZIC5	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Zic5	IDA		Mouse	PMID:15465018
Biological Process	GO:0033278	cell proliferation in midbrain	zic5	IGI	ZFIN:ZDB-GENE-000710-4	Zfish	PMID:17215296
Biological Process	GO:0033278	cell proliferation in midbrain	zic5	IMP		Zfish	PMID:17215296
Biological Process	GO:0033278	cell proliferation in midbrain	zic5	IMP	ZFIN:ZDB-MRPHLNO-070523-1	Zfish	PMID:17215296
Biological Process	GO:0030900	forebrain development	Zic5	IMP	MGI:MGI:3574814	Mouse	PMID:15736266
Biological Process	GO:0030901	midbrain development	zic5	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-070523-1	Zfish	PMID:19470582
Biological Process	GO:0030901	midbrain development	zic5	IMP	ZFIN:ZDB-MRPHLNO-070523-1	Zfish	PMID:17215296
Biological Process	GO:0014033	neural crest cell differentiation	Zic5	IMP	MGI:MGI:3052154	Mouse	PMID:15136147
Biological Process	GO:0001843	neural tube closure	Zic5	IMP	MGI:MGI:3052154	Mouse	PMID:15136147
Biological Process	GO:0001841	neural tube formation	zic5	IGI	ZFIN:ZDB-MRPHLNO-070522-3,ZFIN:ZDB-MRPHLNO-070523-1	Zfish	PMID:19470582
Biological Process	GO:0042127	regulation of cell population proliferation	zic5	IMP	ZFIN:ZDB-MRPHLNO-070523-1	Zfish	PMID:17215296
Biological Process	GO:0050767	regulation of neurogenesis	zic5	IMP	ZFIN:ZDB-MRPHLNO-120605-5	Zfish	PMID:22595676

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern