Zic5
Gene Detail

Symbol Name ID

Zic5 zinc finger protein of the cerebellum 5 MGI:1929518

Synonyms

1700049L20Rik, odd-paired related, Opr

Feature Type

protein coding gene

Genetic Map

Chromosome 14

65.96 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:122456795-122465677 bp, - strand From VEGA annotation of GRCm38   8883 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11301  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog

Gene Tree: Zic5

Human homologs

Human Homolog		ZIC5, Zic family member 5
NCBI Gene ID		85416
neXtProt AC		NX_Q96T25
Human Chr (Location)		13q32.3; chr13:99963021-99971924 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice display postnatal lethality and reduced life spans with exencephaly, abnormal cerebral cortex and diencephalon morphology, abnormal gait and posture, and impaired growth.

 

Interactions

Zic5 interacts with 390 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell differentiation, forebrain development, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (150)    Tissues (114)    Images (31)
Theiler Stages: 2, 3, 4, 5, 8, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 23, 28

Assay Type	Results
RNA in situ	118
RT-PCR	32

cDNA source data(3)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular reagents

All nucleic(7) cDNA(3) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000020976 (Evidence)
Ensembl Gene Model	ENSMUSG00000041703 (Evidence)
Entrez Gene	65100 (Evidence)
NIA Mouse Gene Index	U035955, U045833
Consensus CDS Project	CCDS27348.1
International Mouse Knockout Project Status	Zic5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020976	VEGA Gene Model | MGI Sequence Detail	8883	C57BL/6J
transcript	OTTMUST00000049605	VEGA | MGI Sequence Detail	4767	Not Applicable
polypeptide	OTTMUSP00000023013	VEGA | MGI Sequence Detail	622	Not Applicable

All sequences(22) RefSeq(4) UniProt(2)

Polymorphisms

SNPs within 2kb(13 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017669	zinc finger protein ZIC 5

References

(Earliest) J:65637 Furushima K, et al., A new murine zinc finger gene, Opr. Mech Dev. 2000 Nov;98(1-2):161-4
(Latest) J:198578 Chervenak AP, et al., Spatiotemporal expression of zic genes during vertebrate inner ear development. Dev Dyn. 2013 Jul;242(7):897-908
All references(34)

Other accession IDs

MGI:1920601