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Zic5 Gene Detail
Summary
  • Symbol
    Zic5
  • Name
    zinc finger protein of the cerebellum 5
  • Synonyms
    1700049L20Rik, odd-paired related, Opr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929518
    NCBI Gene: 65100
Location & Maps
more
  • Sequence Map
    Chr14:122456795-122465677 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      8883 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 65.96 cM, cytoband E5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZIC5, Zic family member 5
  • Vertebrate Orthologs
    5
  • Human Ortholog
    ZIC5, Zic family member 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 85416
    neXtProt AC: NX_Q96T25
    UniProt: Q96T25

  • Chr Location
    13q32.3; chr13:99963021-99971924 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal lethality and reduced life spans with exencephaly, abnormal cerebral cortex and diencephalon morphology, abnormal gait and posture, and impaired growth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    143
  • Tissues
    109
  • cDNA Data
    3
  • Literature Summary
    12
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020976 VEGA Gene Model | MGI Sequence Detail 8883 C57BL/6J ±  kb
transcript OTTMUST00000049605 VEGA | MGI Sequence Detail 4767 Not Applicable  
polypeptide OTTMUSP00000023013 VEGA | MGI Sequence Detail 622 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR013087 Zinc finger C2H2-type
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 7
    cDNA 3
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920601
References
more
  • Summaries
    All 31
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:65637 Furushima K, et al., A new murine zinc finger gene, Opr. Mech Dev. 2000 Nov;98(1-2):161-4
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory