Zic5 MGI Mouse Gene Detail - MGI:1929518 - zinc finger protein of the cerebellum 5

Symbol

Zic5
Name

zinc finger protein of the cerebellum 5
Synonyms

1700049L20Rik, odd-paired related, Opr

Feature Type

protein coding gene
IDs

MGI:1929518
NCBI Gene: 65100
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:122459160-122465658 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 65.96 cM, cytoband E5
Mapping Data

2 experiments

SNPs within 2kb

13 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929518	protein coding gene	Chr14:122456795-122465677 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021671	protein coding gene	Chr14:120371455-120380583 (-)
A/J	MGP_AJ_G0021631	protein coding gene	Chr14:115694528-115704767 (-)
AKR/J	MGP_AKRJ_G0021607	protein coding gene	Chr14:119439486-119447990 (-)
BALB/cJ	MGP_BALBcJ_G0021637	protein coding gene	Chr14:116244652-116253532 (-)
C3H/HeJ	MGP_C3HHeJ_G0018086	protein coding gene	Chr11:55642829-55650539 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022077	protein coding gene	Chr14:124987312-124996518 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019615	protein coding gene	Chr14:111556197-111565002 (-)
CAST/EiJ	MGP_CASTEiJ_G0020930	protein coding gene	Chr14:117247639-117256576 (-)
CBA/J	MGP_CBAJ_G0021383	protein coding gene	Chr14:129737113-129745995 (-)
DBA/2J	MGP_DBA2J_G0021506	protein coding gene	Chr14:115552931-115561811 (-)
FVB/NJ	MGP_FVBNJ_G0021484	protein coding gene	Chr14:113906241-113916181 (-)
LP/J	MGP_LPJ_G0021574	protein coding gene	Chr14:121280058-121291772 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021511	protein coding gene	Chr14:134719991-134730097 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022100	protein coding gene	Chr14:119033811-119042713 (-)
PWK/PhJ	MGP_PWKPhJ_G0020674	protein coding gene	Chr14:112616001-112624946 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020512	protein coding gene	Chr14:115205604-115218714 (-)
WSB/EiJ	MGP_WSBEiJ_G0020986	protein coding gene	Chr14:119700855-119709714 (-)

Human Ortholog

ZIC5, Zic family member 5

Vertebrate Orthologs

5

Human Ortholog

ZIC5, Zic family member 5
Orthology source: HomoloGene, HGNC
Links

HGNC:20322

NCBI Gene ID: 85416

neXtProt AC: NX_Q96T25

UniProt: Q96T25
Chr Location

13q32.3; chr13:99963021-99971924 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11301
1 human;1 mouse;1 rat;1 dog;1 macaque, rhesus
HCOP

human homology predictions: ZIC5
Gene Tree

Zic5

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Phenotype Summary

37 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display postnatal lethality and reduced life spans with exencephaly, abnormal cerebral cortex and diencephalon morphology, abnormal gait and posture, and impaired growth.

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All GO Annotations

16
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

169
Tissues

127
cDNA Data

6
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zic5

ZFIN zic5

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Zic5 interacts with 390 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

34
RefSeq

4
UniProt

3
CCDS

CCDS27348.1

Ensembl

ENSMUSG00000041703 (Evidence)
NCBI Gene

65100

			Length	Strain/Species	Flank
genomic	65100	NCBI Gene Model \| MGI Sequence Detail	6499	C57BL/6J	± kb
transcript	NM_022987	RefSeq \| MGI Sequence Detail	2383	C57BL/6
polypeptide	Q7TQ40	UniProt \| EBI \| MGI Sequence Detail	622	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 10

cDNA 6

Primer pair 4

Microarray probesets 4

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MGI:1920601

Summaries

All 33

Developmental Gene Expression 12

Gene Ontology 8

Phenotypes 3
Earliest

J:65637 Furushima K, et al., A new murine zinc finger gene, Opr. Mech Dev. 2000 Nov;98(1-2):161-4
Latest

J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

TSS for Zic5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130337	Chr14:122465454-122465486 (-)	188 bp
Tssr130336	Chr14:122464819-122464877 (-)	810 bp
Tssr130335	Chr14:122464226-122464240 (-)	1,425 bp
Tssr130334	Chr14:122464213-122464224 (-)	1,439 bp
Tssr130333	Chr14:122464163-122464191 (-)	1,481 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 03/13/2019 MGI 6.13