Zic5 MGI Mouse Gene Detail - MGI:1929518 - zinc finger protein of the cerebellum 5

Zic5 Gene Detail

Symbol

Zic5
Name

zinc finger protein of the cerebellum 5
Synonyms

1700049L20Rik, odd-paired related, Opr

Feature Type

protein coding gene
IDs

MGI:1929518
NCBI Gene: 65100

Sequence Map

Chr14:122456795-122465677 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

8883 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 65.96 cM, cytoband E5
Mapping Data

2 experiments

Human Ortholog

ZIC5, Zic family member 5

Vertebrate Orthologs

5

Human Ortholog

ZIC5, Zic family member 5
Orthology source: HomoloGene, HGNC
Links

HGNC:20322

NCBI Gene ID: 85416

neXtProt AC: NX_Q96T25
Chr Location

13q32.3; chr13:99963021-99971924 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 11301
1 human;1 mouse;1 rat;1 rhesus macaque;1 dog
HCOP

human homology predictions: ZIC5
Gene Tree

Zic5

less

Phenotype Summary

37 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC

Homozygous null mice display postnatal lethality and reduced life spans with exencephaly, abnormal cerebral cortex and diencephalon morphology, abnormal gait and posture, and impaired growth.

less

All GO Annotations

13
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

143
Tissues

109
cDNA Data

3
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase zic5

ZFIN zic5

less

Zic5 interacts with 390 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

less

All Sequences

21
RefSeq

4
UniProt

3
CCDS

CCDS27348.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000020976	VEGA Gene Model \| MGI Sequence Detail	8883	C57BL/6J	± kb
transcript	OTTMUST00000049605	VEGA \| MGI Sequence Detail	4767	Not Applicable
polypeptide	OTTMUSP00000023013	VEGA \| MGI Sequence Detail	622	Not Applicable

less

SNPs within 2kb

13 from dbSNP Build 142

less

UniProt

3 Sequences
InterPro Domains

IPR007087 Zinc finger, C2H2

IPR015880 Zinc finger, C2H2-like

IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain

less

All nucleic 7

cDNA 3

Primer pair 4

Microarray probesets 4

less

MGI:1920601

Summaries

All 31

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 3
Earliest

J:65637 Furushima K, et al., A new murine zinc finger gene, Opr. Mech Dev. 2000 Nov;98(1-2):161-4
Latest

J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/27/2016 MGI 6.05