Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Xdh

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes XDH
- Mouse genes Xdh
- Rat genes Xdh
- Zfish genes xdh
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xdh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	XDH	IDA		Human	PMID:17301077
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	Xdh	IDA		Rat	PMID:15878860\|RGD:8553512
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	Xdh	IDA		Rat	PMID:2549869\|RGD:13209004
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	XDH	IDA		Human	PMID:17301077
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	Xdh	IDA		Rat	PMID:15878860\|RGD:8553512
Molecular Function	GO:0070674	hypoxanthine dehydrogenase activity	XDH	IDA		Human	PMID:1619276
Molecular Function	GO:0070674	hypoxanthine dehydrogenase activity	Xdh	IMP		Mouse	PMID:30936145
Molecular Function	GO:0070674	hypoxanthine dehydrogenase activity	Xdh	IDA		Mouse	PMID:8064675
Molecular Function	GO:0070675	hypoxanthine oxidase activity	Xdh	IMP		Mouse	PMID:30936145
Molecular Function	GO:0070675	hypoxanthine oxidase activity	Xdh	IDA		Mouse	PMID:8064675
Molecular Function	GO:0042802	identical protein binding	Xdh	IPI	RGD:62043	Rat	PMID:2549869\|RGD:13209004
Molecular Function	GO:0043546	molybdopterin cofactor binding	XDH	IDA		Human	PMID:17301077
Molecular Function	GO:0043546	molybdopterin cofactor binding	Xdh	IDA		Rat	PMID:15878860\|RGD:8553512
Molecular Function	GO:0050421	nitrite reductase (NO-forming) activity	Xdh	IDA		Rat	PMID:25537183\|RGD:13208960
Molecular Function	GO:0016491	oxidoreductase activity	Xdh	IDA		Mouse	PMID:17597094
Molecular Function	GO:0005515	protein binding	XDH	IPI	UniProtKB:Q9Y3R0-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Xdh	IPI	PR:Q62556	Mouse	PMID:8541302
Molecular Function	GO:0042803	protein homodimerization activity	XDH	IPI	UniProtKB:P47989	Human	PMID:17301077
Molecular Function	GO:0004854	xanthine dehydrogenase activity	XDH	IDA		Human	PMID:8670112
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IDA		Mouse	PMID:1590774
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IDA		Mouse	PMID:8226898
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IDA		Mouse	PMID:29895374
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IDA		Mouse	PMID:8064675
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IDA		Mouse	PMID:12502743
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IDA		Rat	PMID:15878860\|RGD:8553512
Molecular Function	GO:0004854	xanthine dehydrogenase activity	Xdh	IDA		Rat	PMID:2387845\|RGD:61780
Molecular Function	GO:0004855	xanthine oxidase activity	XDH	IDA		Human	PMID:17301077
Molecular Function	GO:0004855	xanthine oxidase activity	XDH	IDA		Human	PMID:8670112
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Mouse	PMID:29895374
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Mouse	PMID:8226898
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Mouse	PMID:1590774
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Mouse	PMID:4207016
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IMP		Mouse	PMID:30936145
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Mouse	PMID:8064675
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Rat	PMID:15878860\|RGD:8553512
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Rat	PMID:2387845\|RGD:61780
Molecular Function	GO:0004855	xanthine oxidase activity	Xdh	IDA		Rat	PMID:3443108\|RGD:42721989
Cellular Component	GO:0005829	cytosol	XDH	IDA		Human	PMID:1619276
Cellular Component	GO:0005829	cytosol	Xdh	IDA		Mouse	PMID:31659168
Cellular Component	GO:0005829	cytosol	Xdh	IDA		Mouse	PMID:1590774
Cellular Component	GO:0005829	cytosol	Xdh	IDA		Mouse	PMID:29895374
Cellular Component	GO:0005829	cytosol	Xdh	IMP		Mouse	PMID:30936145
Cellular Component	GO:0005829	cytosol	Xdh	IDA		Mouse	PMID:8226898
Cellular Component	GO:0005829	cytosol	Xdh	IDA		Rat	PMID:1619276\|RGD:127285395
Cellular Component	GO:0005829	cytosol	Xdh	IDA		Rat	PMID:11913970\|RGD:730052
Cellular Component	GO:0005615	extracellular space	XDH	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Xdh	IDA		Rat	PMID:14728722\|RGD:7247701
Cellular Component	GO:0005777	peroxisome	Xdh	IDA		Rat	PMID:3443108\|RGD:42721989
Cellular Component	GO:0016529	sarcoplasmic reticulum	Xdh	IDA		Mouse	MGI:MGI:5613473\|PMID:19800018
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	XDH	IDA		Human	PMID:18386220
Biological Process	GO:0006154	adenosine catabolic process	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Biological Process	GO:0006154	adenosine catabolic process	Xdh	IDA		Mouse	PMID:29895374
Biological Process	GO:0006154	adenosine catabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0006154	adenosine catabolic process	Xdh	IMP		Mouse	PMID:30936145
Biological Process	GO:0006154	adenosine catabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0006154	adenosine catabolic process	Xdh	IDA		Rat	PMID:1619276\|RGD:127285395
Biological Process	GO:0000255	allantoin metabolic process	XDH	IDA		Human	PMID:1619276
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IDA		Mouse	PMID:30936145
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IDA		Mouse	PMID:29895374
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IDA		Mouse	PMID:8064675
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IMP		Mouse	PMID:30936145
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IDA		Rat	PMID:1619276\|RGD:127285395
Biological Process	GO:0000255	allantoin metabolic process	Xdh	IDA		Rat	PMID:3443108\|RGD:42721989
Biological Process	GO:0043605	amide catabolic process	Xdh	IDA		Mouse	PMID:30936145
Biological Process	GO:0043605	amide catabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0043605	amide catabolic process	Xdh	IDA		Mouse	PMID:29895374
Biological Process	GO:0043605	amide catabolic process	Xdh	IDA		Mouse	PMID:8064675
Biological Process	GO:0043605	amide catabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0043605	amide catabolic process	Xdh	IMP		Mouse	PMID:30936145
Biological Process	GO:0043605	amide catabolic process	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Biological Process	GO:0006196	AMP catabolic process	XDH	IDA		Human	PMID:1619276
Biological Process	GO:0006196	AMP catabolic process	Xdh	IDA		Mouse	PMID:8064675
Biological Process	GO:0071347	cellular response to interleukin-1	Xdh	IEP		Rat	PMID:12653206\|RGD:1624380
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Xdh	IEP		Rat	PMID:12653206\|RGD:1624380
Biological Process	GO:0046059	dAMP catabolic process	Xdh	IDA		Mouse	PMID:8064675
Biological Process	GO:0006157	deoxyadenosine catabolic process	Xdh	IDA		Mouse	PMID:8064675
Biological Process	GO:0006161	deoxyguanosine catabolic process	Xdh	IDA		Mouse	PMID:30936145
Biological Process	GO:0006161	deoxyguanosine catabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0006161	deoxyguanosine catabolic process	Xdh	IDA		Mouse	PMID:29895374
Biological Process	GO:0006149	deoxyinosine catabolic process	XDH	IDA		Human	PMID:1619276
Biological Process	GO:0006149	deoxyinosine catabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0006149	deoxyinosine catabolic process	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Biological Process	GO:0006149	deoxyinosine catabolic process	Xdh	IMP		Mouse	PMID:30936145
Biological Process	GO:0006149	deoxyinosine catabolic process	Xdh	IDA		Mouse	PMID:29895374
Biological Process	GO:0006149	deoxyinosine catabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0046055	dGMP catabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0046055	dGMP catabolic process	Xdh	IDA		Mouse	PMID:29895374
Biological Process	GO:0046055	dGMP catabolic process	Xdh	IDA		Mouse	PMID:30936145
Biological Process	GO:0046038	GMP catabolic process	Xdh	IDA		Mouse	PMID:30936145
Biological Process	GO:0046038	GMP catabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0006147	guanine catabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0006147	guanine catabolic process	Xdh	IDA		Rat	PMID:3443108\|RGD:42721989
Biological Process	GO:0009114	hypoxanthine catabolic process	XDH	IDA		Human	PMID:1619276
Biological Process	GO:0009114	hypoxanthine catabolic process	Xdh	IMP		Mouse	PMID:30936145
Biological Process	GO:0009114	hypoxanthine catabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0009114	hypoxanthine catabolic process	Xdh	IDA		Rat	PMID:232638\|RGD:13210503
Biological Process	GO:0009114	hypoxanthine catabolic process	Xdh	IDA		Rat	PMID:3443108\|RGD:42721989
Biological Process	GO:0006204	IMP catabolic process	XDH	IDA		Human	PMID:1619276
Biological Process	GO:0006204	IMP catabolic process	Xdh	IDA		Mouse	PMID:8064675
Biological Process	GO:0006148	inosine catabolic process	XDH	IDA		Human	PMID:1619276
Biological Process	GO:0006148	inosine catabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0006148	inosine catabolic process	Xdh	IMP		Mouse	PMID:30936145
Biological Process	GO:0006148	inosine catabolic process	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Biological Process	GO:0006148	inosine catabolic process	Xdh	IDA		Mouse	PMID:29895374
Biological Process	GO:0006148	inosine catabolic process	Xdh	IDA		Mouse	PMID:8226898
Biological Process	GO:0006148	inosine catabolic process	Xdh	IDA		Rat	PMID:1619276\|RGD:127285395
Biological Process	GO:0016226	iron-sulfur cluster assembly	Xdh	IDA		Mouse	PMID:17597094
Biological Process	GO:0007595	lactation	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	XDH	IDA		Human	PMID:18386220
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	XDH	IDA		Human	PMID:18386220
Biological Process	GO:0010629	negative regulation of gene expression	XDH	IDA		Human	PMID:18386220
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	XDH	IDA		Human	PMID:18386220
Biological Process	GO:0001933	negative regulation of protein phosphorylation	XDH	IDA		Human	PMID:18386220
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	XDH	IDA		Human	PMID:18386220
Biological Process	GO:2001213	negative regulation of vasculogenesis	XDH	IDA		Human	PMID:18386220
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	XDH	IDA		Human	PMID:18386220
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	XDH	IDA		Human	PMID:18386220
Biological Process	GO:0030856	regulation of epithelial cell differentiation	Xdh	IMP	MGI:MGI:2448161	Mouse	PMID:12502743
Biological Process	GO:0010044	response to aluminum ion	Xdh	IDA		Rat	PMID:11787993\|RGD:730193
Biological Process	GO:0097184	response to azide	Xdh	IEP		Rat	PMID:23174561\|RGD:13210512
Biological Process	GO:0034465	response to carbon monoxide	Xdh	IEP		Rat	PMID:8248931\|RGD:13210748
Biological Process	GO:0009408	response to heat	Xdh	IEP		Rat	PMID:3202896\|RGD:13210576
Biological Process	GO:0042542	response to hydrogen peroxide	Xdh	IEP		Rat	PMID:3162724\|RGD:13209131
Biological Process	GO:0032496	response to lipopolysaccharide	Xdh	IEP		Rat	PMID:24378112\|RGD:13210508
Biological Process	GO:0009115	xanthine catabolic process	XDH	IDA		Human	PMID:17301077
Biological Process	GO:0009115	xanthine catabolic process	XDH	IDA		Human	PMID:8670112
Biological Process	GO:0009115	xanthine catabolic process	Xdh	IDA		Mouse	PMID:1590774
Biological Process	GO:0009115	xanthine catabolic process	Xdh	IDA		Rat	PMID:15878860\|RGD:8553512
Biological Process	GO:0009115	xanthine catabolic process	Xdh	IDA		Rat	PMID:3443108\|RGD:42721989

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.