Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UNC5C
  • Mouse genes Unc5c
  • Rat genes Unc5c
  • Zfish genes unc5ca,unc5cb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Unc5c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005042	netrin receptor activity	Unc5c	IDA		Mouse	PMID:10964959
Molecular Function	GO:0005043	netrin receptor activity involved in chemorepulsion	Unc5c	IDA		Mouse	MGI:MGI:6274971|PMID:22685302
Molecular Function	GO:0005043	netrin receptor activity involved in chemorepulsion	Unc5c	IDA		Mouse	MGI:MGI:5906064|PMID:28483977
Molecular Function	GO:0005515	protein binding	UNC5C	IPI	UniProtKB:O60469	Human	PMID:22685302
Molecular Function	GO:0005515	protein binding	UNC5C	IPI	UniProtKB:Q13509	Human	PMID:28483977
Molecular Function	GO:0005515	protein binding	Unc5c	IPI	UniProtKB:Q9ERC8	Mouse	MGI:MGI:6274971|PMID:22685302
Molecular Function	GO:0005515	protein binding	Unc5c	IPI	UniProtKB:Q9ERD7	Mouse	MGI:MGI:5906064|PMID:28483977
Molecular Function	GO:0005515	protein binding	Unc5c	IPI	PR:O09118	Mouse	PMID:10964959
Molecular Function	GO:0019901	protein kinase binding	UNC5C	IPI	UniProtKB:P53355	Human	PMID:27068745
Molecular Function	GO:0015631	tubulin binding	UNC5C	IPI	UniProtKB:Q13509	Human	PMID:28483977
Molecular Function	GO:0015631	tubulin binding	Unc5c	IPI	UniProtKB:Q9ERD7	Mouse	MGI:MGI:5906064|PMID:28483977
Cellular Component	GO:0030424	axon	Unc5c	IDA		Mouse	MGI:MGI:6274971|PMID:22685302
Cellular Component	GO:0030425	dendrite	Unc5c	IDA		Mouse	MGI:MGI:6274971|PMID:22685302
Cellular Component	GO:0030175	filopodium	Unc5c	IDA		Mouse	MGI:MGI:5906064|PMID:28483977
Cellular Component	GO:0030426	growth cone	Unc5c	IDA		Mouse	MGI:MGI:6274971|PMID:22685302
Cellular Component	GO:0030426	growth cone	Unc5c	IDA		Mouse	MGI:MGI:5906064|PMID:28483977
Cellular Component	GO:0030027	lamellipodium	Unc5c	IDA		Mouse	MGI:MGI:5906064|PMID:28483977
Cellular Component	GO:0043025	neuronal cell body	Unc5c	IDA		Mouse	MGI:MGI:6274971|PMID:22685302
Cellular Component	GO:0005886	plasma membrane	UNC5C	IDA		Human	PMID:25419706
Cellular Component	GO:0005886	plasma membrane	Unc5c	IDA		Mouse	PMID:10964959
Biological Process	GO:0033564	anterior/posterior axon guidance	Unc5c	IMP		Mouse	PMID:18479186
Biological Process	GO:0006915	apoptotic process	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:18077458
Biological Process	GO:0007411	axon guidance	Unc5c	IGI	UniProtKB:Q9ERC8	Mouse	MGI:MGI:6274971|PMID:22685302
Biological Process	GO:0007411	axon guidance	Unc5c	IDA		Mouse	MGI:MGI:6274971|PMID:22685302
Biological Process	GO:0007411	axon guidance	Unc5c	IGI	MGI:MGI:2679336	Mouse	PMID:23144223
Biological Process	GO:0007420	brain development	Unc5c	IMP	MGI:MGI:1857013	Mouse	PMID:1401878
Biological Process	GO:0007420	brain development	Unc5c	IMP	MGI:MGI:1857013	Mouse	PMID:9126743
Biological Process	GO:0007420	brain development	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:10818148
Biological Process	GO:0007420	brain development	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:9126743
Biological Process	GO:0007420	brain development	Unc5c	IMP	MGI:MGI:1857013	Mouse	PMID:9550145
Biological Process	GO:0061643	chemorepulsion of axon	Unc5c	IMP		Mouse	MGI:MGI:5906064|PMID:28483977
Biological Process	GO:1990791	dorsal root ganglion development	UNC5C	IDA		Human	PMID:28483977
Biological Process	GO:0035234	ectopic germ cell programmed cell death	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:18077458
Biological Process	GO:0038007	netrin-activated signaling pathway	Unc5c	IGI	UniProtKB:Q9ERC8	Mouse	MGI:MGI:6274971|PMID:22685302
Biological Process	GO:0043065	positive regulation of apoptotic process	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:18077458
Biological Process	GO:0051094	positive regulation of developmental process	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:18077458
Biological Process	GO:2000243	positive regulation of reproductive process	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:18077458
Biological Process	GO:0030334	regulation of cell migration	Unc5c	IMP	MGI:MGI:1857852	Mouse	PMID:10818148
Biological Process	GO:2001222	regulation of neuron migration	Unc5c	IMP	MGI:MGI:1857013	Mouse	PMID:9389662

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern