Unc5c MGI Mouse Gene Detail - MGI:1095412

Unc5c Gene Detail

Symbol

Unc5c
Name

unc-5 netrin receptor C
Synonyms

B130051O18Rik, Unc5h3

Feature Type

protein coding gene
IDs

MGI:1095412
NCBI Gene: 22253
Gene Overview

MyGene.info: UNC5C

Sequence Map

Chr3:141465216-141834924 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

369709 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 65.57 cM
Mapping Data

6 experiments

Human Ortholog

UNC5C, unc-5 netrin receptor C

Vertebrate Orthologs

10

Human Ortholog

UNC5C, unc-5 netrin receptor C
Orthology source: HomoloGene, HGNC
Synonyms

UNC5H3
Links

HGNC:12569

NCBI Gene ID: 8633

neXtProt AC: NX_O95185
Chr Location

4q21-q23; chr4:95162504-95549210 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 2765
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: UNC5C
Protein SuperFamily

unc-5 protein
Gene Tree

Unc5c

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Phenotype Summary

44 phenotypes from 3 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

1
Radiation induced

1
Spontaneous

1
Targeted

4
Transgenic

2
Genomic Mutations

2 involving Unc5c
Incidental Mutations

Mutagenetix , APF

Mutants exhibit ataxia, and reduced size early in life. Mutants exhibit cerebellar defects including reduced size and ectopic cerebellar cells in the midbrain.

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All GO Annotations

19
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

405
Tissues

179
cDNA Data

49
Literature Summary

44

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA UNC5C

ZFIN unc5c

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Unc5c interacts with 474 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

52
RefSeq

4
UniProt

7
CCDS

CCDS17873.1, CCDS80034.1
UniGene

24430

			Length	Strain/Species	Flank
genomic	OTTMUSG00000025311	VEGA Gene Model \| MGI Sequence Detail	369709	C57BL/6J	± kb
transcript	OTTMUST00000062300	VEGA \| MGI Sequence Detail	3498	Not Applicable
polypeptide	OTTMUSP00000030693	VEGA \| MGI Sequence Detail	950	Not Applicable

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SNPs within 2kb

4461 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000017095 netrin receptor UNC5C
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR000906 ZU5 domain

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All nucleic 59

Genomic 1

cDNA 53

Primer pair 3

Other 2

Microarray probesets 4

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MGD-MRK-13803, MGI:2139620, MGI:2442491, MGI:97881

Summaries

All 88

Developmental Gene Expression 44

Gene Ontology 11

Phenotypes 28
Earliest

J:14268 Lane PW, et al., Rostral cerebellar malformation. Mouse Genome. 1990;86:237
Latest

J:227617 Garrett AM, et al., Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Front Mol Neurosci. 2016;9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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