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Unc5c Gene Detail
Summary
  • Symbol
    Unc5c
  • Name
    unc-5 netrin receptor C
  • Synonyms
    B130051O18Rik, Unc5h3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095412
    NCBI Gene: 22253
  • Gene Overview
    MyGene.info: UNC5C
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr3:141465216-141834924 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      369709 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 65.57 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    UNC5C, unc-5 netrin receptor C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNC5C, unc-5 netrin receptor C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UNC5H3
  • Links
    NCBI Gene ID: 8633
    neXtProt AC: NX_O95185
    UniProt: O95185

  • Chr Location
    4q22.3; chr4:95162504-95549210 (-)  GRCh38.p7
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants exhibit ataxia, and reduced size early in life. Mutants exhibit cerebellar defects including reduced size and ectopic cerebellar cells in the midbrain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    405
  • Tissues
    178
  • cDNA Data
    49
  • Literature Summary
    46
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025311 VEGA Gene Model | MGI Sequence Detail 369709 C57BL/6J ±  kb
transcript OTTMUST00000062297 VEGA | MGI Sequence Detail 3890 Not Applicable  
polypeptide OTTMUSP00000030691 VEGA | MGI Sequence Detail 950 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4461 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 59
    Genomic 1
    cDNA 53
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13803, MGI:2139620, MGI:2442491, MGI:97881
References
more
  • Summaries
    All 95
    Developmental Gene Expression 46
    Diseases 1
    Gene Ontology 11
    Phenotypes 33
  • Earliest
    J:28673 Boyer BB, et al., The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol Cell Biol. 1991 Aug;11(8):4147-56
  • Latest
    J:256148 Varadarajan SG, et al., Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord. Neuron. 2017 May 17;94(4):790-799.e3
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory