About   Help   FAQ
Unc5c Gene Detail
Summary
  • Symbol
    Unc5c
  • Name
    unc-5 netrin receptor C
  • Synonyms
    B130051O18Rik, Unc5h3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095412
    NCBI Gene: 22253
  • Gene Overview
    MyGene.info: UNC5C
Location & Maps
more
  • Sequence Map
    Chr3:141465216-141834924 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      369709 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    UNC5C, unc-5 netrin receptor C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNC5C, unc-5 netrin receptor C
    Orthology source: HomoloGene
  • Synonyms
    UNC5H3
  • Links
    NCBI Gene ID: 8633
    neXtProt AC: NX_O95185

  • Chr Location
    4q21-q23; chr4:95162504-95549210 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    2
  • Genomic Mutations
    2 involving Unc5c
  • Incidental Mutations
Mutants exhibit ataxia, and reduced size early in life. Mutants exhibit cerebellar defects including reduced size and ectopic cerebellar cells in the midbrain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025311 VEGA Gene Model | MGI Sequence Detail 369709 C57BL/6J ±  kb
transcript OTTMUST00000062297 VEGA | MGI Sequence Detail 3890 Not Applicable  
polypeptide OTTMUSP00000030691 VEGA | MGI Sequence Detail 950 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    4461 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    Genomic 1
    cDNA 53
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13803, MGI:2139620, MGI:2442491, MGI:97881
References
more
  • Summaries
    All 88
    Developmental Gene Expression 44
    Gene Ontology 11
    Phenotypes 28
  • Earliest
    J:14268 Lane PW, et al., Rostral cerebellar malformation. Mouse Genome. 1990;86:237
  • Latest
    J:227617 Garrett AM, et al., Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Front Mol Neurosci. 2016;9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory