Unc5c MGI Mouse Gene Detail - MGI:1095412

Symbol

Unc5c
Name

unc-5 netrin receptor C
Synonyms

B130051O18Rik, Unc5h3

Feature Type

protein coding gene
IDs

MGI:1095412
NCBI Gene: 22253
Gene Overview

MyGene.info: UNC5C
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:141465564-141834924 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 65.57 cM
Mapping Data

6 experiments

SNPs within 2kb

4461 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1095412	protein coding gene	Chr3:141465216-141834924 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027938	protein coding gene	Chr3:144616922-144984695 (+)
A/J	MGP_AJ_G0027895	protein coding gene	Chr3:139499204-139863732 (+)
AKR/J	MGP_AKRJ_G0027861	protein coding gene	Chr3:143187683-143554073 (+)
BALB/cJ	MGP_BALBcJ_G0027907	protein coding gene	Chr3:139297886-139668601 (+)
C3H/HeJ	MGP_C3HHeJ_G0027637	protein coding gene	Chr3:143531117-143909925 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028351	protein coding gene	Chr3:149676259-150054134 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025689	protein coding gene	Chr3:134747385-135099287 (+)
CAST/EiJ	MGP_CASTEiJ_G0027093	protein coding gene	Chr3:143415607-143800388 (+)
CBA/J	MGP_CBAJ_G0027614	protein coding gene	Chr3:154803155-155199775 (+)
DBA/2J	MGP_DBA2J_G0027753	protein coding gene	Chr3:138605987-138963336 (+)
FVB/NJ	MGP_FVBNJ_G0027720	protein coding gene	Chr3:136055446-136415291 (+)
LP/J	MGP_LPJ_G0027863	protein coding gene	Chr3:146062671-146437937 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027752	protein coding gene	Chr3:163111584-163523434 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028409	protein coding gene	Chr3:142797304-143162832 (+)
PWK/PhJ	MGP_PWKPhJ_G0026817	protein coding gene	Chr3:138415443-138779058 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026644	protein coding gene	Chr3:140879152-141250447 (+)
WSB/EiJ	MGP_WSBEiJ_G0027172	protein coding gene	Chr3:143660675-144032342 (+)

Human Ortholog

UNC5C, unc-5 netrin receptor C

Vertebrate Orthologs

10

Human Ortholog

UNC5C, unc-5 netrin receptor C
Orthology source: HomoloGene, HGNC
Synonyms

UNC5H3
Links

HGNC:12569

NCBI Gene ID: 8633

neXtProt AC: NX_O95185

UniProt: O95185
Chr Location

4q22.3; chr4:95162504-95549210 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2765
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: UNC5C
Protein SuperFamily

unc-5 protein
Gene Tree

Unc5c

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References

1 with disease annotations

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Phenotype Summary

47 phenotypes from 4 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Spontaneous

1
Targeted

4
Transgenic

2
Genomic Mutations

2 involving Unc5c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutants exhibit ataxia, and reduced size early in life. Mutants exhibit cerebellar defects including reduced size and ectopic cerebellar cells in the midbrain.

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All GO Annotations

42
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1095
Tissues

210
cDNA Data

52
Literature Summary

54

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA UNC5C

ZFIN unc5c

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Unc5c interacts with 474 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

57
RefSeq

4
UniProt

7
CCDS

CCDS17873.1, CCDS80034.1
UniGene

24430

Ensembl

ENSMUSG00000059921 (Evidence)
NCBI Gene

22253

			Length	Strain/Species	Flank
genomic	22253	NCBI Gene Model \| MGI Sequence Detail	369361	C57BL/6J	± kb
transcript	NM_001293561	RefSeq \| MGI Sequence Detail	9355	C57BL/6
polypeptide	O08747	UniProt \| EBI \| MGI Sequence Detail	931	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017095 netrin receptor UNC5C

(term hierarchy)
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR037936 Netrin receptor UNC5

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR042154 UNC5C, death domain

IPR033772 UPA domain

IPR000906 ZU5 domain

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All nucleic 64

Genomic 1

cDNA 56

Primer pair 5

Other 2

Microarray probesets 4

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MGD-MRK-13803, MGI:2139620, MGI:2442491, MGI:97881

Summaries

All 108

Developmental Gene Expression 54

Diseases 1

Gene Ontology 15

Phenotypes 38
Earliest

J:28673 Boyer BB, et al., The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol Cell Biol. 1991 Aug;11(8):4147-56
Latest

J:297714 Brignani S, et al., Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron. 2020 Aug 19;107(4):684-702.e9

TSS for Unc5c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32031	Chr3:141465116-141465129 (+)	-441 bp
Tssr32032	Chr3:141465179-141465223 (+)	-363 bp
Tssr1066	Chr3:141465261-141465269 (+)	-299 bp
Tssr32033	Chr3:141465371-141465381 (+)	-188 bp
Tssr32034	Chr3:141465486-141465491 (+)	-75 bp
Tssr32035	Chr3:141465542-141465549 (+)	-18 bp
Tssr32036	Chr3:141465567-141465570 (+)	5 bp
Tssr32037	Chr3:141465592-141465611 (+)	38 bp
Tssr1067	Chr3:141465654-141465664 (+)	95 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/06/2021 MGI 6.16