Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRH
  • Mouse genes Trh
  • Rat genes Trh
  • Zfish genes trh
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TRH	IPI	UniProtKB:P80188	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TRH	IPI	UniProtKB:Q6PIL6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Trh	IPI	MGI:MGI:2177284	Mouse	PMID:11181534
Molecular Function	GO:0008437	thyrotropin-releasing hormone activity	Trh	IDA		Rat	PMID:12369739|RGD:634240
Cellular Component	GO:0005737	cytoplasm	Trh	IDA		Rat	PMID:3930986|RGD:1600428
Cellular Component	GO:0005634	nucleus	Trh	IDA		Rat	PMID:3930986|RGD:1600428
Cellular Component	GO:0005886	plasma membrane	Trh	IDA		Rat	PMID:3930986|RGD:1600428
Cellular Component	GO:0030141	secretory granule	Trh	IDA		Rat	PMID:3930986|RGD:1600428
Biological Process	GO:0007628	adult walking behavior	Trh	IGI	MGI:MGI:109482	Mouse	PMID:8719807
Biological Process	GO:0042755	eating behavior	Trh	IDA		Rat	PMID:16959836|RGD:1600409
Biological Process	GO:0001692	histamine metabolic process	Trh	IDA		Rat	PMID:17760865|RGD:7241067
Biological Process	GO:2000252	negative regulation of feeding behavior	Trh	IDA		Rat	PMID:17760865|RGD:7241067
Biological Process	GO:0014050	negative regulation of glutamate secretion	Trh	IDA		Rat	PMID:16055093|RGD:1600422
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	Trh	IDA		Rat	PMID:16990402|RGD:1600408
Biological Process	GO:0032024	positive regulation of insulin secretion	Trh	IDA		Rat	PMID:16118471|RGD:1600419
Biological Process	GO:0009409	response to cold	Trh	IEP		Rat	PMID:16629836|RGD:1600416
Biological Process	GO:0051412	response to corticosterone	Trh	IEP		Rat	PMID:16293347|RGD:1600418
Biological Process	GO:0045471	response to ethanol	Trh	IEP		Rat	PMID:15680480|RGD:1600426
Biological Process	GO:0009749	response to glucose	Trh	IEP		Rat	PMID:15680480|RGD:1600426
Biological Process	GO:0001666	response to hypoxia	Trh	IEP		Rat	PMID:15726019|RGD:1600425
Biological Process	GO:0014070	response to organic cyclic compound	Trh	IEP		Rat	PMID:16075386|RGD:1600421

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern