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Trh Gene Detail
Summary
  • Symbol
    Trh
  • Name
    thyrotropin releasing hormone
  • Feature Type
    protein coding gene
  • IDs
    MGI:98823
    NCBI Gene: 22044
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:92219042-92221631 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 41.03 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98823
 protein coding gene Chr6:92219042-92221631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031058
 protein coding gene Chr6:93881782-93884368 (-)
A/J MGP_AJ_G0031027
 protein coding gene Chr6:90311139-90313725 (-)
AKR/J MGP_AKRJ_G0030958
 protein coding gene Chr6:92801387-92803976 (-)
BALB/cJ MGP_BALBcJ_G0031038
 protein coding gene Chr6:90271915-90274501 (-)
C3H/HeJ MGP_C3HHeJ_G0030670
 protein coding gene Chr6:91621515-91624104 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031497
 protein coding gene Chr6:96293520-96296109 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028664
 protein coding gene Chr6:88285059-88287634 (-)
CAST/EiJ MGP_CASTEiJ_G0030145
 protein coding gene Chr6:92939298-92941824 (-)
CBA/J MGP_CBAJ_G0030724
 protein coding gene Chr6:99873782-99876371 (-)
DBA/2J MGP_DBA2J_G0030877
 protein coding gene Chr6:89486286-89488872 (-)
FVB/NJ MGP_FVBNJ_G0030831
 protein coding gene Chr6:88697901-88700490 (-)
LP/J MGP_LPJ_G0030957
 protein coding gene Chr6:93832687-93835273 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030865
 protein coding gene Chr6:103911608-103914197 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031524
 protein coding gene Chr6:92661059-92663645 (-)
PWK/PhJ MGP_PWKPhJ_G0029861
 protein coding gene Chr6:88447134-88449713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029690
 protein coding gene Chr6:91572055-91574653 (-)
WSB/EiJ MGP_WSBEiJ_G0030229
 protein coding gene Chr6:93127322-93129957 (-)



Homology
more
  • Human Ortholog
    TRH, thyrotropin releasing hormone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRH, thyrotropin releasing hormone
  • Synonyms
    Pro-TRH, TRF
  • Links
    NCBI Gene ID: 7200
    neXtProt AC: NX_P20396
    UniProt: P20396

  • Chr Location
    3q22.1; chr3:129974688-129977935 (+)  GRCh38
  • MGI Vertebrate Homology
    Trh stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: TRH
  • Protein SuperFamily
    TRH
  • Gene Tree
    Trh
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    65
  • cDNA Data
    23
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22044 NCBI Gene Model | MGI Sequence Detail 2590 C57BL/6J ±  kb
    transcript NM_009426 RefSeq | MGI Sequence Detail 1400 ZRU/MplStud  
    polypeptide Q62361 UniProt | EBI | MGI Sequence Detail 256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 3
      cDNA 23
      Primer pair 6
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15226, MGI:2141394, MGI:2141525
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 38
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:46607 Katakami H, et al., Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency. J Endocrinol Invest. 1984 Jun;7(3):231-3
    • Latest
      J:341948 Valli E, et al., Hypothyroidism-associated immunosuppression involves induction of galectin-1-producing regulatory T cells. FASEB J. 2023 Apr;37(4):e22865
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory