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Trh
Gene Detail
Symbol

Name
ID
Trh
thyrotropin releasing hormone
MGI:98823
Feature Type
protein coding gene
Genetic Map
Chromosome 6
41.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:92242061-92244650 bp, - strand
From VEGA annotation of GRCm38

  2590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5163  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TRH
Protein SuperFamily: thyroliberin
Gene Tree: Trh

Human
homologs
TRH, thyrotropin-releasing hormone
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7200
neXtProt AC: NX_P20396

Human Synonyms: Pro-TRH, TRF

Human Chr (Location): 3q13.3-q21; chr3:129974393-129977938 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TRH

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Spontaneous(1) Targeted(3)
Genomic Mutations involving Trh (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
 
Interactions
Trh interacts with 102 markers (Mir27a, Mir31, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process adult walking behavior, eating behavior, ...
Component cytoplasm, extracellular region, ...
Function hormone activity, neuropeptide hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (156)    Tissues (55)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
Northern blot 4
RT-PCR 7
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TRH ; Xenbase trh    NEW 
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(21) Primer pair(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024415 (Evidence)
Ensembl Gene Model ENSMUSG00000005892 (Evidence)
Entrez Gene 22044 (Evidence)
UniGene 1363
DFCI TC1584830
DoTS DT.101366709, DT.527747
NIA Mouse Gene Index U027644
Consensus CDS Project CCDS20375.1
International Mouse Phenotyping Consortium Status Trh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024415 VEGA Gene Model | MGI Sequence Detail 2590 C57BL/6J ±  kb
transcript OTTMUST00000059849 VEGA | MGI Sequence Detail 1384 Not Applicable 
polypeptide OTTMUSP00000029149 VEGA | MGI Sequence Detail 256 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008857 Thyrotropin-releasing hormone
Protein Ontology PR:000016635 prothyroliberin
References
(Earliest) J:46607 Katakami H, et al., Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency. J Endocrinol Invest. 1984 Jun;7(3):231-3
(Latest) J:207472 Krashes MJ, et al., An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13;507(7491):238-42
All references(71)
Other
accession IDs
MGD-MRK-15226, MGI:2141394, MGI:2141525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory