Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TREM1
  • Mouse genes Trem1
  • Rat genes Trem1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trem1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140677	molecular function activator activity	TREM1	IDA		Human	PMID:17098818
Molecular Function	GO:0097110	scaffold protein binding	TREM1	IPI	UniProtKB:O43914	Human	PMID:11602640
Molecular Function	GO:0004888	transmembrane signaling receptor activity	TREM1	IDA		Human	PMID:17098818
Cellular Component	GO:0009986	cell surface	TREM1	IDA		Human	PMID:17098818
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Trem1	IEP		Rat	PMID:26383906|RGD:127284850
Biological Process	GO:0071305	cellular response to vitamin D	Trem1	IEP		Rat	PMID:29331667|RGD:127284861
Biological Process	GO:0032602	chemokine production	Trem1	IGI	MGI:MGI:1930003	Mouse	PMID:23241959
Biological Process	GO:0001816	cytokine production	Trem1	IGI	MGI:MGI:1930003	Mouse	PMID:23241959
Biological Process	GO:0002367	cytokine production involved in immune response	Trem1	IGI	MGI:MGI:1930003	Mouse	PMID:23241959
Biological Process	GO:0030593	neutrophil chemotaxis	Trem1	IGI	MGI:MGI:1930003	Mouse	PMID:23241959
Biological Process	GO:0072672	neutrophil extravasation	Trem1	IGI	MGI:MGI:1930003	Mouse	PMID:23241959
Biological Process	GO:1990266	neutrophil migration	Trem1	IGI	MGI:MGI:1930003	Mouse	PMID:23241959
Biological Process	GO:0070945	neutrophil-mediated killing of gram-negative bacterium	Trem1	IGI	MGI:MGI:1930003	Mouse	PMID:23241959
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Trem1	IMP		Rat	PMID:33495812|RGD:127229929
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	Trem1	IDA		Rat	PMID:29331667|RGD:127284861
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	Trem1	IMP		Rat	PMID:29331667|RGD:127284861
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Trem1	IDA		Rat	PMID:29331667|RGD:127284861
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Trem1	IMP		Rat	PMID:29331667|RGD:127284861

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern