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Trem1 Gene Detail
Summary
  • Symbol
    Trem1
  • Name
    triggering receptor expressed on myeloid cells 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930005
    NCBI Gene: 58217
  • Gene Overview
    MyGene.info: TREM1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48232768-48246924 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930005
protein coding gene Chr17:48232362-48246924 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023864
protein coding gene Chr17:49500947-49515074 (+)
A/J MGP_AJ_G0023824
protein coding gene Chr17:48206618-48220775 (+)
AKR/J MGP_AKRJ_G0023792
protein coding gene Chr17:48680379-48694528 (+)
BALB/cJ MGP_BALBcJ_G0023826
protein coding gene Chr17:48133910-48148057 (+)
C3H/HeJ MGP_C3HHeJ_G0023589
protein coding gene Chr17:49387464-49401617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024269
protein coding gene Chr17:51605356-51619499 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021718
protein coding gene Chr17:44974847-44984915 (+)
CAST/EiJ MGP_CASTEiJ_G0023071
protein coding gene Chr17:49570082-49584353 (+)
CBA/J MGP_CBAJ_G0023565
protein coding gene Chr17:53449015-53463168 (+)
DBA/2J MGP_DBA2J_G0023694
protein coding gene Chr17:46978051-46992200 (+)
FVB/NJ MGP_FVBNJ_G0023660
protein coding gene Chr17:46638386-46652546 (+)
LP/J MGP_LPJ_G0023774
protein coding gene Chr17:50209692-50223834 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023688
protein coding gene Chr17:52946842-52960998 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024315
protein coding gene Chr17:49020085-49034241 (+)
PWK/PhJ MGP_PWKPhJ_G0022816
protein coding gene Chr17:46400691-46414946 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022630
protein coding gene Chr17:45914481-45928999 (+)
WSB/EiJ MGP_WSBEiJ_G0023135
protein coding gene Chr17:49605292-49619422 (+)



Homology
more
  • Human Ortholog
    TREM1, triggering receptor expressed on myeloid cells 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TREM1, triggering receptor expressed on myeloid cells 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD354, TREM-1
  • Links
    NCBI Gene ID: 54210
    neXtProt AC: NX_Q9NP99
    UniProt: Q9NP99

  • Chr Location
    6p21.1; chr6:41267385-41286745 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit decreased susceptibility to DEN induced tumors and liver damage. Mice homozygous for a knock-out allele of Trem1 and Trem3 exhibit increased susceptibility to P. aeruginosa infection with reduced neutrophil transepithelial migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042265 Ensembl Gene Model | MGI Sequence Detail 14157 C57BL/6J ±  kb
    transcript ENSMUST00000048782 Ensembl | MGI Sequence Detail 2993 Not Applicable  
    polypeptide ENSMUSP00000038636 Ensembl | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:64954 Bouchon A, et al., Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5
    • Latest
      J:257271 Saurer L, et al., TREM-1 promotes intestinal tumorigenesis. Sci Rep. 2017 Nov 1;7(1):14870

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory