Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM67
  • Mouse genes Tmem67
  • Rat genes Tmem67
  • Zfish genes tmem67
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem67

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031005	filamin binding	TMEM67	IPI	UniProtKB:P21333	Human	PMID:22121117
Molecular Function	GO:0051787	misfolded protein binding	Tmem67	IDA		Rat	PMID:19815549|RGD:8554391
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:Q9NXB0	Human	PMID:17185389
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:P08582	Human	PMID:19815549
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:Q8IXB1	Human	PMID:19815549
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:Q9UBS3	Human	PMID:19815549
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:Q01974	Human	PMID:26035863
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:P05067-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:P41221	Human	PMID:34731008
Molecular Function	GO:0005515	protein binding	TMEM67	IPI	UniProtKB:A2RU14	Human	PMID:35137054
Molecular Function	GO:0051082	unfolded protein binding	TMEM67	IPI	UniProtKB:P11686	Human	PMID:19815549
Cellular Component	GO:0005930	axoneme	Tmem67	IDA		Rat	PMID:23516626|RGD:11535084
Cellular Component	GO:0005813	centrosome	TMEM67	IDA		Human	PMID:17185389
Cellular Component	GO:0060170	ciliary membrane	TMEM67	IDA		Human	PMID:17185389
Cellular Component	GO:0035869	ciliary transition zone	TMEM67	IDA		Human	PMID:26595381
Cellular Component	GO:0005929	cilium	Tmem67	IDA		Rat	PMID:23516626|RGD:11535084
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	TMEM67	IDA		Human	PMID:19815549
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Tmem67	IDA		Mouse	MGI:MGI:4441110|PMID:19815549
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	Tmem67	IDA		Rat	PMID:19815549|RGD:8554391
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TMEM67	IDA		Human	PMID:19815549
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Tmem67	IDA		Mouse	MGI:MGI:4441110|PMID:19815549
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Tmem67	IDA		Rat	PMID:19815549|RGD:8554391
Cellular Component	GO:0036038	MKS complex	Tmem67	IDA		Mouse	MGI:MGI:5288576|PMID:21725307
Cellular Component	GO:0005886	plasma membrane	Tmem67	IDA		Rat	PMID:19815549|RGD:8554391
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Tmem67	IMP		Mouse	MGI:MGI:4441259|PMID:17185389
Biological Process	GO:0060271	cilium assembly	TMEM67	IMP		Human	PMID:19515853
Biological Process	GO:0060271	cilium assembly	Tmem67	IMP		Mouse	MGI:MGI:4441259|PMID:17185389
Biological Process	GO:0060271	cilium assembly	Tmem67	IMP		Mouse	MGI:MGI:4353840|PMID:19515853
Biological Process	GO:0060271	cilium assembly	Tmem67	IMP		Mouse	MGI:MGI:5288576|PMID:21725307
Biological Process	GO:0060271	cilium assembly	Tmem67	IMP		Rat	PMID:19515853|RGD:8554306
Biological Process	GO:0060271	cilium assembly	tmem67	IGI	ZFIN:ZDB-MRPHLNO-080716-5,ZFIN:ZDB-MRPHLNO-120320-1	Zfish	PMID:22121117
Biological Process	GO:0060271	cilium assembly	tmem67	IMP	ZFIN:ZDB-MRPHLNO-080716-5	Zfish	PMID:22121117
Biological Process	GO:0003341	cilium movement	tmem67	IMP	ZFIN:ZDB-MRPHLNO-130603-2	Zfish	PMID:23393159
Biological Process	GO:0060028	convergent extension involved in axis elongation	tmem67	IMP	ZFIN:ZDB-MRPHLNO-130603-1	Zfish	PMID:23393159
Biological Process	GO:0060027	convergent extension involved in gastrulation	tmem67	IGI	ZFIN:ZDB-MRPHLNO-120111-8,ZFIN:ZDB-MRPHLNO-120111-9	Zfish	PMID:22152675
Biological Process	GO:0007368	determination of left/right symmetry	Tmem67	IMP		Mouse	PMID:25807483
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Tmem67	IMP		Mouse	MGI:MGI:5648757|PMID:26035863
Biological Process	GO:0007369	gastrulation	tmem67	IGI	ZFIN:ZDB-MRPHLNO-080716-5,ZFIN:ZDB-MRPHLNO-080716-9	Zfish	PMID:18327255
Biological Process	GO:0060322	head development	Tmem67	IMP		Rat	PMID:30705305|RGD:14995942
Biological Process	GO:0007507	heart development	Tmem67	IMP		Mouse	PMID:25807483
Biological Process	GO:0001822	kidney development	Tmem67	IMP	MGI:MGI:5437086	Mouse	PMID:27002738
Biological Process	GO:0001822	kidney development	Tmem67	IMP	MGI:MGI:5433409	Mouse	PMID:27002738
Biological Process	GO:0010826	negative regulation of centrosome duplication	TMEM67	IMP		Human	PMID:19515853
Biological Process	GO:0010826	negative regulation of centrosome duplication	Tmem67	IMP		Mouse	MGI:MGI:4353840|PMID:19515853
Biological Process	GO:0010826	negative regulation of centrosome duplication	Tmem67	IMP		Rat	PMID:19515853|RGD:8554306
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	TMEM67	IMP		Human	PMID:34964473
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	Tmem67	IMP		Mouse	MGI:MGI:5648757|PMID:26035863
Biological Process	GO:0035845	photoreceptor cell outer segment organization	Tmem67	IMP		Rat	PMID:23516626|RGD:11535084
Biological Process	GO:1904294	positive regulation of ERAD pathway	Tmem67	IMP		Rat	PMID:19815549|RGD:8554391
Biological Process	GO:1902857	positive regulation of non-motile cilium assembly	Tmem67	IMP		Rat	PMID:21614130|RGD:11535947
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	TMEM67	IMP		Human	PMID:19815549

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern