Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLX1
  • Mouse genes Tlx1
  • Rat genes Tlx1
  • Zfish genes tlx1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tlx1	IDA		Mouse	MGI:MGI:3581070|PMID:15944191
Molecular Function	GO:0005515	protein binding	TLX1	IPI	UniProtKB:O00470	Human	PMID:19559479
Molecular Function	GO:0005515	protein binding	TLX1	IPI	UniProtKB:O14770-2	Human	PMID:19559479
Molecular Function	GO:0005515	protein binding	TLX1	IPI	UniProtKB:P40424-2	Human	PMID:19559479
Molecular Function	GO:0005515	protein binding	TLX1	IPI	UniProtKB:P40425	Human	PMID:19559479
Molecular Function	GO:0005515	protein binding	TLX1	IPI	UniProtKB:P27577	Human	PMID:22516263
Molecular Function	GO:0005515	protein binding	TLX1	IPI	UniProtKB:P40425	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Tlx1	IPI	PR:P41778	Mouse	PMID:15944191
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tlx1	IDA		Mouse	MGI:MGI:3581070|PMID:15944191
Biological Process	GO:0048645	animal organ formation	Tlx1	IMP	MGI:MGI:3581680	Mouse	PMID:11356032
Biological Process	GO:0045165	cell fate commitment	Tlx1	IMP	MGI:MGI:3581680	Mouse	PMID:11356032
Biological Process	GO:0008283	cell population proliferation	Tlx1	IMP	MGI:MGI:1857260	Mouse	PMID:15944191
Biological Process	GO:0007417	central nervous system development	Tlx1	IMP	MGI:MGI:1857260	Mouse	PMID:12023301
Biological Process	GO:0030182	neuron differentiation	Tlx1	IMP	MGI:MGI:1857260	Mouse	PMID:12023301
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Tlx1	IMP	MGI:MGI:1857260	Mouse	PMID:15944191
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tlx1	IDA		Mouse	PMID:15944191
Biological Process	GO:0050776	regulation of immune response	tlx1	IMP	ZFIN:ZDB-GENO-211101-2	Zfish	PMID:34262881
Biological Process	GO:0048536	spleen development	Tlx1	IGI	MGI:MGI:97495	Mouse	PMID:15944191
Biological Process	GO:0048536	spleen development	Tlx1	IMP	MGI:MGI:3581680	Mouse	PMID:11356032
Biological Process	GO:0048536	spleen development	tlx1	IMP	ZFIN:ZDB-GENO-211101-2	Zfish	PMID:31678534
Biological Process	GO:0048536	spleen development	tlx1	IMP	ZFIN:ZDB-GENO-211101-3	Zfish	PMID:31678534
Biological Process	GO:0072089	stem cell proliferation	Tlx1	IMP	MGI:MGI:1857260	Mouse	PMID:15944191

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern