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Tlx1
Gene Detail
 Symbol
Name
ID
Tlx1
T cell leukemia, homeobox 1
MGI:98769
Synonyms Hox11, Hox-11
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr19:45150680-45156943 bp, + strand
From VEGA annotation of GRCm38

  6264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tlx1

Human
homologs
Human Homolog TLX1, T-cell leukemia homeobox 1
NCBI Gene ID 3195
neXtProt AC  NX_P31314
Human Synonyms  HOX11, TCL3
Human Chr (Location)  10q24; chr10:101131304-101137789 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygous mutant embryos show cellular disorganization at the site of splenic development and never develop a spleen.
 
Interactions
Tlx1 interacts with 134 markers (Mir20a, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell fate commitment, central nervous system development, ...
Component nucleus
Function DNA binding, protein heterodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (400)    Tissues (244)    Images (93)
Theiler Stages: 12, 13, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 336
In situ reporter (knock in) 28
RT-PCR 36
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(8) cDNA(7) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037553 (Evidence)
Ensembl Gene ModelENSMUSG00000025215 (Evidence)
Entrez Gene21908 (Evidence)
UniGene391203
DFCITC1593082
DoTSDT.91316550
NIA Mouse Gene IndexU144329
Consensus CDS ProjectCCDS29858.1
International Mouse Knockout Project StatusTlx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037553 VEGA Gene Model | MGI Sequence Detail 6264 C57BL/6J ±  kb
transcript OTTMUST00000096809 VEGA | MGI Sequence Detail 2065 Not Applicable 
polypeptide OTTMUSP00000054129 VEGA | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000016383 T-cell leukemia homeobox protein 1
References (Earliest) J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
(Latest) J:196292 Marinic M, et al., An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev Cell. 2013 Mar 11;24(5):530-42
All references(80)
Other
accession IDs
MGD-MRK-10827, MGD-MRK-15137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory