About   Help   FAQ
Tlx1
Gene Detail
Symbol

Name
ID
Tlx1
T cell leukemia, homeobox 1
MGI:98769
Synonyms
Hox11, Hox-11
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr19:45150680-45156943 bp, + strand
From VEGA annotation of GRCm38

  6264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TLX1
Gene Tree: Tlx1

Human
homologs
TLX1, T-cell leukemia homeobox 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3195
neXtProt AC: NX_P31314

Human Synonyms: HOX11, TCL3

Human Chr (Location): 10q24; chr10:101130780-101137789 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
 
Homozygous mutant embryos show cellular disorganization at the site of splenic development and never develop a spleen.
 
Interactions
Tlx1 interacts with 134 markers (Mir20a, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (28 records)
Data Summary: Results (400)    Tissues (243)    Images (93)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 336
In situ reporter (knock in) 28
RT-PCR 36
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tlx1 ; ZFIN tlx1    NEW 
Molecular
reagents
All nucleic(19) Genomic(8) cDNA(7) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037553 (Evidence)
Ensembl Gene Model ENSMUSG00000025215 (Evidence)
Entrez Gene 21908 (Evidence)
UniGene 391203
DFCI TC1593082
DoTS DT.91316550
NIA Mouse Gene Index U144329
Consensus CDS Project CCDS29858.1
International Mouse Phenotyping Consortium Status Tlx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037553 VEGA Gene Model | MGI Sequence Detail 6264 C57BL/6J ±  kb
transcript OTTMUST00000096809 VEGA | MGI Sequence Detail 2065 Not Applicable 
polypeptide OTTMUSP00000054129 VEGA | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000016383 T-cell leukemia homeobox protein 1
References
(Earliest) J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
(Latest) J:219573 Van Praet JT, et al., Commensal microbiota influence systemic autoimmune responses. EMBO J. 2015 Feb 12;34(4):466-74
All references(79)
Other
accession IDs
MGD-MRK-10827, MGD-MRK-15137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory