About   Help   FAQ
Tlx1 Gene Detail
Summary
  • Symbol
    Tlx1
  • Name
    T cell leukemia, homeobox 1
  • Synonyms
    Hox-11, Hox11
  • Feature Type
    protein coding gene
  • IDs
    MGI:98769
    NCBI Gene: 21908
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45139119-45145382 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.45 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    264 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98769
 protein coding gene Chr19:45138531-45145382 (+)
129S1/SvImJ ENSMUSG00200019914
 protein coding gene Chr19:41847897-41854176 (+)
A/J ENSMUSG00195015268
 protein coding gene Chr19:41983072-41989336 (+)
AKR/J ENSMUSG00220019240
 protein coding gene Chr19:41782292-41788562 (+)
BALB/cJ ENSMUSG00180018458
 protein coding gene Chr19:42235402-42241666 (+)
C3H/HeJ ENSMUSG00175006163
 protein coding gene Chr19:41765236-41771510 (+)
C57BL/6NJ ENSMUSG00215004506
 protein coding gene Chr19:41830172-41836442 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023013
 protein coding gene Chr19:41811672-41817921 (+)
CAST/EiJ ENSTCUG00005015384
 protein coding gene Chr19:41420593-41426882 (+)
CBA/J ENSMUSG00210018948
 protein coding gene Chr19:41844970-41851239 (+)
DBA/2J ENSMUSG00185008621
 protein coding gene Chr19:42359005-42365268 (+)
FVB/NJ ENSMUSG00205017665
 protein coding gene Chr19:41271605-41277882 (+)
JF1/MsJ ENSUMUG00000042201
 protein coding gene Chr19:42501952-42508203 (+)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190004946
 protein coding gene Chr19:41719834-41726099 (+)
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010001093
 protein coding gene Chr19:41665974-41672223 (+)
SPRET/EiJ ENSMSPG00010007660
 protein coding gene Chr19:41414056-41420416 (+)
WSB/EiJ ENSIUOG00005006126
 protein coding gene Chr19:41220448-41226664 (+)



Homology
more
  • Human Ortholog
    TLX1, T cell leukemia homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLX1, T cell leukemia homeobox 1
  • Synonyms
    HOX11, TCL3
  • Links
    NCBI Gene ID: 3195
    UniProt: P31314

  • Chr Location
    10q24.31; chr10:101131300-101137789 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TLX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant embryos show cellular disorganization at the site of splenic development and never develop a spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1156
  • Tissues
    302
  • cDNA Data
    8
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025215 Ensembl Gene Model | MGI Sequence Detail 6264 C57BL/6J ±  kb
    transcript ENSMUST00000026236 Ensembl | MGI Sequence Detail 2065 Not Applicable  
    polypeptide ENSMUSP00000026236 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 8
      cDNA 8
      Primer pair 7
      Other 9

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10827, MGD-MRK-15137
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 33
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
    • Latest
      J:388279 Mujal AM, et al., Splenic TNF-alpha signaling potentiates the innate-to-adaptive transition of antiviral NK cells. Immunity. 2025 Mar 11;58(3):585-600.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory