Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLR1
  • Mouse genes Tlr1
  • Rat genes Tlr1
  • Zfish genes tlr1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tlr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TLR1	IPI	UniProtKB:Q15399	Human	PMID:23155421
Molecular Function	GO:0071723	lipopeptide binding	Tlr1	IDA		Rat	PMID:16973131|RGD:1643119
Molecular Function	GO:0005515	protein binding	TLR1	IPI	UniProtKB:Q9BXR5	Human	PMID:15728506
Molecular Function	GO:0005515	protein binding	TLR1	IPI	UniProtKB:O60603,UniProtKB:P08571	Human	PMID:16880211
Molecular Function	GO:0005515	protein binding	TLR1	IPI	UniProtKB:O60603	Human	PMID:23155421
Molecular Function	GO:0005515	protein binding	TLR1	IPI	UniProtKB:Q9BXR5	Human	PMID:23155421
Molecular Function	GO:0035663	Toll-like receptor 2 binding	TLR1	IPI	UniProtKB:O60603	Human	PMID:16880211
Cellular Component	GO:0005794	Golgi apparatus	TLR1	IDA		Human	PMID:16880211
Cellular Component	GO:0045121	membrane raft	TLR1	IDA		Human	PMID:16880211
Cellular Component	GO:0043235	receptor complex	TLR1	IPI		Human	PMID:23155421
Cellular Component	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	TLR1	IPI		Human	PMID:17889651
Cellular Component	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	TLR1	IDA		Human	PMID:17889651
Biological Process	GO:0071727	cellular response to triacyl bacterial lipopeptide	TLR1	IDA		Human	PMID:19931471
Biological Process	GO:0071727	cellular response to triacyl bacterial lipopeptide	TLR1	IDA		Human	PMID:16880211
Biological Process	GO:0006952	defense response	Tlr1	IMP	MGI:MGI:3526882	Mouse	PMID:12091878
Biological Process	GO:0042495	detection of triacyl bacterial lipopeptide	TLR1	IDA		Human	PMID:19931471
Biological Process	GO:0001774	microglial cell activation	Tlr1	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tlr1	IMP		Mouse	MGI:MGI:3609367|PMID:12077222
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TLR1	IGI	ComplexPortal:CPX-1134,UniProtKB:O60603	Human	PMID:22198949
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	TLR1	IGI	ComplexPortal:CPX-1134,UniProtKB:O60603	Human	PMID:22198949
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tlr1	IMP		Mouse	MGI:MGI:3609367|PMID:12077222
Biological Process	GO:0032493	response to bacterial lipoprotein	Tlr1	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0002224	toll-like receptor signaling pathway	TLR1	IDA		Human	PMID:16893894
Biological Process	GO:0002224	toll-like receptor signaling pathway	Tlr1	IDA		Rat	PMID:16973131|RGD:1643119

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern