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Tlr1
Gene Detail
Symbol

Name
ID
Tlr1
toll-like receptor 1
MGI:1341295
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:64924679-64933563 bp, - strand
From VEGA annotation of GRCm38

  8885 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20694  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: TLR1
Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr1

Human
homologs
TLR1, toll-like receptor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7096
neXtProt AC: NX_Q15399

Human Synonyms: CD281, rsc786, TIL, TIL. LPRS5

Human Chr (Location): 4p14; chr4:38787555-38805800 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TLR1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Tlr1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display decreased macrophage peptoglycan-stimulated IL-6 production.
 
Phenotype Images(4)
Interactions
Tlr1 interacts with 35 markers (Mir7-1, Mir7-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495171 ; ZFIN tlr1    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000055138 (Evidence)
Ensembl Gene Model ENSMUSG00000044827 (Evidence)
Entrez Gene 21897 (Evidence)
UniGene 273024
DFCI TC1582770
DoTS DT.110632611, DT.530385
NIA Mouse Gene Index U026238
Consensus CDS Project CCDS19302.1
International Mouse Phenotyping Consortium Status Tlr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055138 VEGA Gene Model | MGI Sequence Detail 8885 C57BL/6J ±  kb
transcript OTTMUST00000136535 VEGA | MGI Sequence Detail 3025 Not Applicable 
polypeptide OTTMUSP00000072041 VEGA | MGI Sequence Detail 795 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(20) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(159 from dbSNP Build 137)    SNPs within 2kb including multiple locations(183)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027190 Toll-like receptor 1
Protein Ontology PR:000001151 Toll-like receptor 1
References
(Earliest) J:54928 Takeuchi O, et al., TLR6: A novel member of an expanding toll-like receptor family. Gene. 1999 Apr 29;231(1-2):59-65
(Latest) J:209973 Shen KY, et al., Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells. J Immunol. 2014 May 1;192(9):4233-41
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory