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Tlr1
Gene Detail
Symbol

Name
ID
Tlr1
toll-like receptor 1
MGI:1341295
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:64924811-64932761 bp, - strand
From Ensembl annotation of GRCm38

  7951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20694  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: toll-like receptor, 1/2/4/6/10 types
Gene Tree: Tlr1

Human
homologs
Human Homolog TLR1, toll-like receptor 1
NCBI Gene ID 7096
neXtProt AC  NX_Q15399
Human Synonyms  CD281, rsc786, TIL, TIL. LPRS5
Human Chr (Location)  4p14; chr4:38796255-38805193 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TLR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display decreased macrophage peptoglycan-stimulated IL-6 production.
 
Interactions
Tlr1 interacts with 35 markers (Mir7-1, Mir7-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000044827 (Evidence)
Entrez Gene21897 (Evidence)
UniGene273024
DFCITC1582770
DoTSDT.530385, DT.110632611
NIA Mouse Gene IndexU026238
Consensus CDS ProjectCCDS19302.1
International Mouse Knockout Project StatusTlr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044827 Ensembl Gene Model | MGI Sequence Detail 7951 C57BL/6J ±  kb
transcript ENSMUST00000059349 Ensembl | MGI Sequence Detail 2652 Not Applicable 
polypeptide ENSMUSP00000060793 Ensembl | MGI Sequence Detail 795 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(18) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(152 from dbSNP Build 137)    SNPs within 2kb including multiple locations(176)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017241 Toll-like receptor
InterPro IPR027190 Toll-like receptor 1
Protein Ontology PR:000001151 Toll-like receptor 1
References
(Earliest) J:54928 Takeuchi O, et al., TLR6: A novel member of an expanding toll-like receptor family. Gene. 1999 Apr 29;231(1-2):59-65
(Latest) J:209973 Shen KY, et al., Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells. J Immunol. 2014 May 1;192(9):4233-41
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory