Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TLE1
  • Mouse genes Tle1
  • Rat genes Tle1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tle1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Tle1	IDA		Mouse	PMID:16002402
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TLE1	IPI	UniProtKB:Q04666	Human	PMID:8687460
Molecular Function	GO:0042802	identical protein binding	TLE1	IPI	UniProtKB:Q04724	Human	PMID:24596249
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:P32182	Human	PMID:10748198
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:O95343	Human	PMID:12441302
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q15038	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q96EB6	Human	PMID:17680780
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q15038	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q9HC29	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q15038	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:A4PIW0	Human	PMID:22439931
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:P55316	Human	PMID:24356439
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:P62805	Human	PMID:24596249
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:P07686	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q9UBB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q01196-1	Human	PMID:9751710
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q01196-2	Human	PMID:9751710
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q13761	Human	PMID:9751710
Molecular Function	GO:0005515	protein binding	TLE1	IPI	UniProtKB:Q9UJU2	Human	PMID:9751710
Molecular Function	GO:0005515	protein binding	Tle1	IPI	UniProtKB:P35428|UniProtKB:Q9WV93	Mouse	MGI:MGI:5285519|PMID:21259317
Molecular Function	GO:0005515	protein binding	Tle1	IPI	PR:Q62440	Mouse	PMID:12359720
Molecular Function	GO:0005515	protein binding	Tle1	IPI	PR:P52955	Mouse	PMID:15528197
Molecular Function	GO:0005515	protein binding	Tle1	IPI	PR:O08686	Mouse	PMID:15528197
Molecular Function	GO:0005515	protein binding	Tle1	IPI	PR:Q60987	Mouse	PMID:16314515
Molecular Function	GO:0003714	transcription corepressor activity	TLE1	IDA		Human	PMID:10748198
Molecular Function	GO:0003714	transcription corepressor activity	Tle1	IDA		Mouse	PMID:15528197
Cellular Component	GO:1990907	beta-catenin-TCF complex	TLE1	IDA		Human	PMID:28296634
Cellular Component	GO:0005829	cytosol	TLE1	IMP		Human	PMID:22952044
Cellular Component	GO:0005654	nucleoplasm	TLE1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	TLE1	IDA		Human	PMID:10748198
Cellular Component	GO:0005634	nucleus	TLE1	IMP		Human	PMID:22952044
Cellular Component	GO:0005634	nucleus	Tle1	IDA		Mouse	PMID:12359720
Cellular Component	GO:0005667	transcription regulator complex	Tle1	IDA		Mouse	PMID:15528197
Biological Process	GO:2000811	negative regulation of anoikis	TLE1	IMP		Human	PMID:15006356
Biological Process	GO:2000811	negative regulation of anoikis	TLE1	IMP		Human	PMID:22952044
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	TLE1	IDA		Human	PMID:9751710
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	TLE1	IDA		Human	PMID:17680780
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tle1	IDA		Mouse	PMID:15528197
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Tle1	IDA		Mouse	PMID:12359720
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	TLE1	IDA		Human	PMID:9751710
Biological Process	GO:0010628	positive regulation of gene expression	TLE1	IMP		Human	PMID:15006356
Biological Process	GO:0006355	regulation of DNA-templated transcription	Tle1	IDA		Mouse	PMID:15528197
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Tle1	IGI	MGI:MGI:109617	Mouse	PMID:15528197

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern