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Tle1
Gene Detail
Symbol

Name
ID
Tle1
transducin-like enhancer of split 1, homolog of Drosophila E(spl)
MGI:104636
Synonyms
C230057C06Rik, Estm14, Grg1, Tle4l
Feature Type
protein coding gene
Genetic Map
Chromosome 4
36.06 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:72117805-72200893 bp, - strand
From VEGA annotation of GRCm38

  83089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TLE1
Protein SuperFamily: transducin-like enhancer protein
Gene Tree: Tle1

Human
homologs
TLE1, transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7088
neXtProt AC: NX_Q04724

Human Synonyms: ESG, ESG1, GRG1

Human Chr (Location): 9q21.32; chr9:81583683-81689535 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(10)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tle1 interacts with 209 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process negative regulation of anoikis, negative regulation of I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (268)    Tissues (174)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 234
Western blot 3
RT-PCR 12
cDNA source data(22)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tle1    NEW 
Molecular
reagents
All nucleic(28) cDNA(25) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000333 (Evidence)
Ensembl Gene Model ENSMUSG00000008305 (Evidence)
Entrez Gene 21885 (Evidence)
DFCI TC1621099, TC1598372, TC1589766, TC1583492, TC1575500, TC1755738, TC1762614
DoTS DT.91335859, DT.531395, DT.101142183, DT.50315018, DT.101188300, DT.97353397, DT.91424067, DT.91371655
NIA Mouse Gene Index U025182, U237870, U217712
Consensus CDS Project CCDS18274.1, CCDS71407.1
International Mouse Phenotyping Consortium Status Tle1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000333 VEGA Gene Model | MGI Sequence Detail 83089 C57BL/6J ±  kb
transcript OTTMUST00000000853 VEGA | MGI Sequence Detail 2569 Not Applicable 
polypeptide OTTMUSP00000000393 VEGA | MGI Sequence Detail 780 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(40) UniProt(8)
Polymorphisms
SNPs within 2kb(674 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005617 Groucho/TLE, N-terminal Q-rich domain
InterPro IPR009146 Groucho/transducin-like enhancer
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000016372 transducin-like enhancer protein 1
References
(Earliest) J:29516 Mallo M, et al., Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Dev Dyn. 1995 Nov;204(3):338-47
(Latest) J:197141 Tuoc TC, et al., Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness. Dev Cell. 2013 May 13;25(3):256-69
All references(69)
Other
accession IDs
MGD-MRK-26073, MGI:2178299, MGI:2444832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory