Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIGAR
  • Mouse genes Tigar
  • Rat genes Tigar
  • Zfish genes tigara,tigarb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tigar

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003824	catalytic activity	tigarb	IDA		Zfish	PMID:19015259
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	TIGAR	EXP		Human	PMID:16839880
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	TIGAR	IDA		Human	PMID:19015259
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Tigar	IMP		Mouse	PMID:20935145
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	tigarb	IDA		Zfish	PMID:19015259|ZFIN:ZDB-PUB-140530-5
Molecular Function	GO:0005515	protein binding	TIGAR	IPI	UniProtKB:P52789	Human	PMID:23185017
Molecular Function	GO:0005515	protein binding	TIGAR	IPI	UniProtKB:O00291	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TIGAR	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TIGAR	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TIGAR	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Cellular Component	GO:0005737	cytoplasm	TIGAR	IDA		Human	PMID:23185017
Cellular Component	GO:0005737	cytoplasm	TIGAR	IDA		Human	PMID:25928429
Cellular Component	GO:0005737	cytoplasm	Tigar	IDA		Mouse	MGI:MGI:5574521|PMID:24872551
Cellular Component	GO:0005829	cytosol	TIGAR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005741	mitochondrial outer membrane	TIGAR	IDA		Human	PMID:23185017
Cellular Component	GO:0005739	mitochondrion	Tigar	IDA		Mouse	MGI:MGI:5574521|PMID:24872551
Cellular Component	GO:0005634	nucleus	TIGAR	IDA		Human	PMID:25928429
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Tigar	IMP	MGI:MGI:5319187	Mouse	PMID:22044588
Biological Process	GO:0071279	cellular response to cobalt ion	TIGAR	IDA		Human	PMID:25928429
Biological Process	GO:0071456	cellular response to hypoxia	TIGAR	IDA		Human	PMID:23185017
Biological Process	GO:0006974	DNA damage response	TIGAR	IDA		Human	PMID:25928429
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	TIGAR	IDA		Human	PMID:19015259
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	tigarb	IDA		Zfish	PMID:19015259|ZFIN:ZDB-PUB-140530-5
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	TIGAR	IDA		Human	PMID:19015259
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	Tigar	IMP		Mouse	PMID:20935145
Biological Process	GO:0006003	fructose 2,6-bisphosphate metabolic process	tigarb	IDA		Zfish	PMID:19015259|ZFIN:ZDB-PUB-140530-5
Biological Process	GO:0019661	glucose catabolic process to lactate via pyruvate	Tigar	IMP		Mouse	PMID:20935145
Biological Process	GO:0006096	glycolytic process	Tigar	IDA		Mouse	PMID:20935145
Biological Process	GO:0060576	intestinal epithelial cell development	Tigar	IMP	MGI:MGI:4391656	Mouse	PMID:23726973
Biological Process	GO:0000423	mitophagy	Tigar	IMP	MGI:MGI:5319187	Mouse	PMID:22044588
Biological Process	GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate	Tigar	IMP		Mouse	PMID:20935145
Biological Process	GO:0045820	negative regulation of glycolytic process	Tigar	IDA		Mouse	PMID:20935145
Biological Process	GO:1901525	negative regulation of mitophagy	Tigar	IMP	MGI:MGI:5319187	Mouse	PMID:22044588
Biological Process	GO:1901215	negative regulation of neuron death	Tigar	IDA		Mouse	MGI:MGI:5574521|PMID:24872551
Biological Process	GO:0043069	negative regulation of programmed cell death	TIGAR	IDA		Human	PMID:23185017
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	Tigar	IMP	MGI:MGI:5319187	Mouse	PMID:22044588
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Tigar	IMP	MGI:MGI:5319187	Mouse	PMID:22044588
Biological Process	GO:0045739	positive regulation of DNA repair	TIGAR	IMP		Human	PMID:25928429
Biological Process	GO:1903301	positive regulation of hexokinase activity	TIGAR	IDA		Human	PMID:23185017
Biological Process	GO:0072593	reactive oxygen species metabolic process	Tigar	IMP	MGI:MGI:5319187	Mouse	PMID:22044588
Biological Process	GO:0043456	regulation of pentose-phosphate shunt	TIGAR	IMP		Human	PMID:25928429
Biological Process	GO:1902153	regulation of response to DNA damage checkpoint signaling	TIGAR	IMP		Human	PMID:25928429
Biological Process	GO:0010332	response to gamma radiation	Tigar	IMP	MGI:MGI:4391656	Mouse	PMID:23726973
Biological Process	GO:0002931	response to ischemia	Tigar	IDA		Mouse	MGI:MGI:5574521|PMID:24872551
Biological Process	GO:0009410	response to xenobiotic stimulus	Tigar	IMP	MGI:MGI:4391656	Mouse	PMID:23726973

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern