9630033F20Rik
Gene Detail

Symbol Name ID

9630033F20Rik RIKEN cDNA 9630033F20 gene MGI:2442752

Synonyms

Tigar

Feature Type

protein coding gene

Genetic Map

Chromosome 6

61.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:127085116-127109550 bp, - strand From VEGA annotation of GRCm38   24435 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32473  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cofactor-dependent phosphoglycerate mutase
Gene Tree: 9630033F20Rik

Human homologs

Human Homolog		C12orf5, chromosome 12 open reading frame 5
NCBI Gene ID		57103
neXtProt AC		NX_Q9NQ88
Human Synonyms		FR2BP, TIGAR
Human Chr (Location)		12p13.3; chr12:4430359-4469194 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(82) : Targeted(4) Gene trapped(78)
 

Mice homozygous for a knock-out allele exhibit improved response to myocardial infarction associated with increased autophagy, mitophagy, levels of reactive oxygen species production and decreased mitochondria DNA damage.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	metabolic process, negative regulation of macromitophagy, ...
Component	intracellular
Function	catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, ...

External Resources: FuncBase

Expression

cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(24) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000024108 (Evidence)
Ensembl Gene Model	ENSMUSG00000038028 (Evidence)
Entrez Gene	319801 (Evidence)
UniGene	101836
DFCI	TC1583610, TC1611465, TC1629401
DoTS	DT.101128529, DT.101372237, DT.522058, DT.91310317
NIA Mouse Gene Index	U027882
EC	3.1.3.46
Consensus CDS Project	CCDS20563.1
International Mouse Knockout Project Status	9630033F20Rik

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024108	VEGA Gene Model | MGI Sequence Detail	24435	C57BL/6J
transcript	OTTMUST00000058971	VEGA | MGI Sequence Detail	3651	Not Applicable
polypeptide	OTTMUSP00000028647	VEGA | MGI Sequence Detail	269	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(141 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013078	Histidine phosphatase superfamily, clade-1
InterPro	IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183674 Hoshino A, et al., p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol. 2012 Jan;52(1):175-84
All references(37)

Other accession IDs

MGI:2141452, MGI:2141756, MGI:3035180, MGI:3035247