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Tigar Gene Detail
Summary
  • Symbol
    Tigar
  • Name
    Trp53 induced glycolysis repulatory phosphatase
  • Synonyms
    9630033F20Rik, Tigar
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442752
    NCBI Gene: 319801
  • Gene Overview
    MyGene.info: TIGAR
Location & Maps
more
  • Sequence Map
    Chr6:127085116-127109557 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24442 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 61.92 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TIGAR, TP53 induced glycolysis regulatory phosphatase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TIGAR, TP53 induced glycolysis regulatory phosphatase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C12orf5, FR2BP
  • Links
    NCBI Gene ID: 57103
    neXtProt AC: NX_Q9NQ88

  • Chr Location
    12p13.3; chr12:4321193-4360028 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    84
  • Gene trapped
    78
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit improved response to myocardial infarction associated with increased autophagy, mitophagy, levels of reactive oxygen species production and decreased mitochondria DNA damage. Mice homozygous for a different allele exhibit impaired crypt regeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024108 VEGA Gene Model | MGI Sequence Detail 24442 C57BL/6J ±  kb
transcript OTTMUST00000058971 VEGA | MGI Sequence Detail 3651 Not Applicable  
polypeptide OTTMUSP00000028647 VEGA | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    210 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000038631 fructose-2,6-bisphosphatase TIGAR
  • EC
  • InterPro Domains
    IPR029033 Histidine phosphatase superfamily
    IPR013078 Histidine phosphatase superfamily, clade-1
    IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site
Molecular
Reagents
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  • All nucleic 26
    cDNA 24
    Other 2

    Microarray probesets 7
Other
Accession IDs
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MGI:2141452, MGI:2141756, MGI:3035180, MGI:3035247
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:227691 Cheung EC, et al., Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev. 2016 Jan 1;30(1):52-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory