Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPON2
  • Mouse genes Spon2
  • Rat genes Spon2
  • Zfish genes spon2a,spon2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spon2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003823	antigen binding	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Molecular Function	GO:0003823	antigen binding	Spon2	IDA		Mouse	PMID:14691481
Molecular Function	GO:0001530	lipopolysaccharide binding	Spon2	IDA		Mouse	PMID:14691481
Molecular Function	GO:0005515	protein binding	SPON2	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SPON2	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPON2	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPON2	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPON2	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Spon2	IPI	PR:P09225	Mouse	PMID:14691481
Molecular Function	GO:0005102	signaling receptor binding	Spon2	IDA		Rat	PMID:10409509|RGD:1299546
Cellular Component	GO:0070062	extracellular exosome	SPON2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SPON2	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	Spon2	IDA		Mouse	PMID:14691481
Cellular Component	GO:0031012	extracellular matrix	spon2a	IDA		Zfish	PMID:9441663
Cellular Component	GO:0031012	extracellular matrix	spon2b	IDA		Zfish	PMID:9441663
Cellular Component	GO:0005615	extracellular space	Spon2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0007155	cell adhesion	Spon2	IDA		Rat	PMID:10409509|RGD:1299546
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0042742	defense response to bacterium	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0050832	defense response to fungus	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0051607	defense response to virus	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0043152	induction of bacterial agglutination	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0045087	innate immune response	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0032635	interleukin-6 production	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0032635	interleukin-6 production	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0002448	mast cell mediated immunity	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0008228	opsonization	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0008228	opsonization	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0032496	response to lipopolysaccharide	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481
Biological Process	GO:0032640	tumor necrosis factor production	Spon2	IDA		Mouse	PMID:14691481
Biological Process	GO:0032640	tumor necrosis factor production	Spon2	IMP	MGI:MGI:3026870	Mouse	PMID:14691481

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern