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Spon2 Gene Detail
Summary
  • Symbol
    Spon2
  • Name
    spondin 2, extracellular matrix protein
  • Synonyms
    2310045I24Rik, Mindin, M-spondin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923724
    NCBI Gene: 100689
Location & Maps
more
  • Sequence Map
    Chr5:33198184-33218455 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20272 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.50 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPON2, spondin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPON2, spondin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIL1, DIL-1, MINDIN, M-SPONDIN
  • Links
    NCBI Gene ID: 10417
    neXtProt AC: NX_Q9BUD6

  • Chr Location
    4p16.3; chr4:1166932-1208962 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40843
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPON2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    7 involving Spon2
  • Incidental Mutations
Mice homozygous for disruptions in this gene have an essentially normal phenotype. There is some alteration in succeptibility to bacterial infection however.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055359 VEGA Gene Model | MGI Sequence Detail 20272 C57BL/6J ±  kb
transcript OTTMUST00000137051 VEGA | MGI Sequence Detail 2045 Not Applicable  
polypeptide OTTMUSP00000072231 VEGA | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    221 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140924
References
more
  • Summaries
    All 31
    Diseases 1
    Gene Ontology 4
    Phenotypes 29
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:143351 Li Z, et al., The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace. J Leukoc Biol. 2009 Jan;85(1):124-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory