Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPNS1
  • Mouse genes Spns1
  • Rat genes Spns1
  • Zfish genes spns1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spns1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPNS1	IPI	UniProtKB:Q07817	Human	PMID:12815463
Cellular Component	GO:0005765	lysosomal membrane	SPNS1	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	Spns1	IMP		Mouse	PMID:36161949
Biological Process	GO:0097352	autophagosome maturation	spns1	IMP	ZFIN:ZDB-MRPHLNO-081229-2	Zfish	PMID:24967584
Biological Process	GO:0097352	autophagosome maturation	spns1	IMP	ZFIN:ZDB-GENO-081229-1	Zfish	PMID:24967584
Biological Process	GO:0006914	autophagy	spns1	IGI	ZFIN:ZDB-MRPHLNO-081229-2,ZFIN:ZDB-MRPHLNO-141015-1	Zfish	PMID:24967584
Biological Process	GO:0006914	autophagy	spns1	IGI	ZFIN:ZDB-MRPHLNO-070126-7,ZFIN:ZDB-MRPHLNO-081229-2	Zfish	PMID:24967584
Biological Process	GO:0090398	cellular senescence	spns1	IGI	ZFIN:ZDB-GENO-141104-6	Zfish	PMID:24967584
Biological Process	GO:0090398	cellular senescence	spns1	IGI	ZFIN:ZDB-GENO-141104-6,ZFIN:ZDB-MRPHLNO-141015-1	Zfish	PMID:24967584
Biological Process	GO:0090398	cellular senescence	spns1	IGI	ZFIN:ZDB-MRPHLNO-081229-2,ZFIN:ZDB-MRPHLNO-141015-1	Zfish	PMID:24967584
Biological Process	GO:0090398	cellular senescence	spns1	IMP	ZFIN:ZDB-MRPHLNO-081229-2	Zfish	PMID:24967584
Biological Process	GO:0051977	lysophospholipid transport	Spns1	IMP		Mouse	PMID:36161949
Biological Process	GO:0033700	phospholipid efflux	Spns1	IMP		Mouse	PMID:36161949
Biological Process	GO:0035751	regulation of lysosomal lumen pH	Spns1	IMP		Mouse	PMID:36161949

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern